KV1.8 channels

Channel name KV1.8
Description Voltage-gated potassium channel, delayed rectifier
Other names KV1.10, Kcn11,2,3,4,5
Molecular information Human: 511aa, NM_005549, chr. 1p13.1, KCNA10, GeneID: 3744, PMID: 91777731
Mouse: 503aa, XM_143471 (predicted), chr. 3
Rat: 511aa, XM_227577 (predicted), chr. 2q34
Associated subunits KCNA4B
Functional assays Voltage-clamp
Current Possibly a component of IKur in the heart2
Conductance 10–12pS2
Ion selectivity K+/Na+ > 70:12
Activation Va =3.6 mV (oocytes); τa =18 ms at +60 mV (oocytes)2
Inactivation τh = 10 s
Activators CGMP
Gating inhibitors None
Blockers Barium (5 mM), tetraethyammonium (50 mM), 4-aminopyridine (1.5 mM), charybdotoxin (100 nM), ketoconazole (500 nM), pimozide (300 nM), verapamil (45 μM)2
Radioligands None
Channel distribution Kidney (cortex > medulla), brain, heart, skeletal muscle, adrenal gland1,2,3,6
Physiological functions Regulation of membrane potential in renal proximal tubule
Mutations and pathophysiology None
Pharmacological significance Not established
Comments Can coassemble with other KV1 family members in heteromultimers but not with members of other KV families; intronless coding region; mammalian Shaker-related family
  • aa, amino acids; chr., chromosome.

  • 1. Orias M, Bray-Ward P, Curran ME, Keating MT, and Desir GV (1997) Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics 42:33-37

  • 2. Lang R, Lee G, Liu W, Tian S, Rafi H, OriasM, Segal AS, and Desir GV (2000) KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. Am J Physiol 278:F1013-F1021

  • 3. Yao X, Segal AS, Welling P, Zhang X, McNicholas CM, Engel D, Boulpaep EL, and Desir GV (1995) Primary structure and functional expression of a cGMP-gated potassium channel. Proc Natl Acad Sci USA 92:11711-11715

  • 4. Yao X, Liu Y, Tung F, and Desir GV (1996) Genomic structure and regulation of Kcn1, a cGMP-gated potassium channel. Am J Physiol 271:F37-F41

  • 5. Iwasa H, Kurabayashi M, Nagai R, Nakamura Y, and Tanaka T (2001) Genetic variations in five genes involved in the excitement of cardiomyocytes. J Hum Genet 46:549-552

  • 6. UniGene Cluster Hs0.306973; OMIM no. 176268