K2P12.1 channels

Channel name K2P12.1
Description Two-pore domain potassium channel subunit1
Other names KCNK12, THIK-2
Molecular information Human: 430aa, NM_022055, chr0.2p22-p21, KCNK12, GeneID: 56660, PMID: 110603161
Rat: 430aa, NM_022292, kcnk12
Mouse: not cloned
Associated subunits Not established
Functional assays Electrophysiological
Current Not established (see “Comments”)1,2
Conductance No function demonstrated
Ion selectivity Not established
Activation Not established
Inactivation Not established
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Brain, heart, lung, kidney, liver, small intestine, colon, pancreas, prostate, placenta, spleen, thymus, ovary
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments The product of this gene has not yet been shown to be a functional channel
  • aa, amino acids; chr., chromosome.

  • 1. Rajan S, Wischmeyer E, Karschin C, Preisig-Muller R, Grzeschik KH, Daut J, Karschin A, and Derst C (2001) THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J Biol Chem 276:7302-7311

  • 2. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, and Lesage F (2001) Genomic and functional characteristics of novel human pancreatic 2P domain K+ channels. Biochem Biophys Res Commun 282:249-256