K2P13.1 channels

Channel name K2P13.1
Description Two-pore domain potassium channel subunit; open rectifier1
Other names KCNK13, THIK-1
Molecular information Human: 408aa, NM_022054, chr0.14q24.1-24.3, KCNK13, GeneID: 56659, PMID: 110603161
Rat: 405aa, NM_022293, kcnk13
Mouse: not cloned
Associated subunits Not established
Functional assays Electrophysiological
Current Open rectifier
Conductance Not established
Ion selectivity Not established
Activation See “Comments”
Inactivation See “Comments”
Activators Arachidonic acid (0.98 mM)
Gating inhibitors None
Blockers Ba2+, halothane (2.83 mM)
Radioligands None
Channel distribution Brain, heart, lung, kidney, liver, spleen
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments Activation and deactivation with voltage steps seem to be instantaneous; K2P13-like channels are found in the central nervous system of Aplysia californica2
  • aa, amino acids; chr., chromosome.

  • 1. Rajan S, Wischmeyer E, Karschin C, Preisig-Muller R, Grzeschik KH, Daut J, Karschin A, and Derst C (2001) THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J Biol Chem 276:7302-7311

  • 2. Jezzini SH and Moroz LL (2004) Identification and distribution of a two-pore domain potassium channel in the CNS of Aplysia californica. Brain Res Mol Brain Res 27:7-38