TRPV3 channel

Channel name TRPV31,2,3,4,5
Description Warmth sensor channel
Other names None
Molecular information Human unigene: Hs0.446255, chr. 17p13.2
Mouse unigene: Mm0.347652, chr. 11 B4
Associated subunits Not established
Functional assays Patch-clamp, calcium imaging
Current Outwardly rectifying nonselective cation current
Conductance 170pS
Ion selectivity PNa/PCa = 0.08
Activation ∼35°C
Inactivation Cooling
Activators Increasing temperature
Gating inhibitors None
Blockers Ruthenium red
Radioligands None
Channel distribution Brain (cortex, thalamus), skin, hair follicles, tongue, stomach, spinal cord, superior cervical ganglion, dorsal root ganglion, trigeminal ganglion
Physiological functions Putative, warm sensation
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments Like TRPV1 and TRPV2, TRPV3 exhibits sensitivity to temperature changes; unique features are hysteresis behavior on heating and cooling and sensitization
  • chr., chromosome.

  • 1. Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, Bevan S, and Patapoutian A (2002) A heat sensitive TRP channel expressed in keratinocytes. Science (Wash DC) 296:2046-2049

  • 2. Xu H, Ramsey, I. Kotecha SA, Moran, M. Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, et al. (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature (Lond) 418:181-186

  • 3. Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, et al. (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature (Lond) 418:186-190

  • 4. Chung MK, Lee H, Mizuno A, Suzuki M, and Caterina M (2004a) TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J Biol Chem 279:21569-21575

  • 5. Hu HZ, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kawada M, Lee LY, Wood JD, and Zhu MX (2004) 2-Aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2 and TRPV3. J Biol Chem 279:35741-35748