TRPV3 channel
| Channel name | TRPV31,2,3,4,5 |
| Description | Warmth sensor channel |
| Other names | None |
| Molecular information | Human unigene: Hs0.446255, chr. 17p13.2 |
| Mouse unigene: Mm0.347652, chr. 11 B4 | |
| Associated subunits | Not established |
| Functional assays | Patch-clamp, calcium imaging |
| Current | Outwardly rectifying nonselective cation current |
| Conductance | 170pS |
| Ion selectivity | PNa/PCa = 0.08 |
| Activation | ∼35°C |
| Inactivation | Cooling |
| Activators | Increasing temperature |
| Gating inhibitors | None |
| Blockers | Ruthenium red |
| Radioligands | None |
| Channel distribution | Brain (cortex, thalamus), skin, hair follicles, tongue, stomach, spinal cord, superior cervical ganglion, dorsal root ganglion, trigeminal ganglion |
| Physiological functions | Putative, warm sensation |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | Like TRPV1 and TRPV2, TRPV3 exhibits sensitivity to temperature changes; unique features are hysteresis behavior on heating and cooling and sensitization |
chr., chromosome.
↵1. Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, Bevan S, and Patapoutian A (2002) A heat sensitive TRP channel expressed in keratinocytes. Science (Wash DC) 296:2046-2049
↵2. Xu H, Ramsey, I. Kotecha SA, Moran, M. Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, et al. (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature (Lond) 418:181-186
↵3. Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, et al. (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature (Lond) 418:186-190
↵4. Chung MK, Lee H, Mizuno A, Suzuki M, and Caterina M (2004a) TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J Biol Chem 279:21569-21575
↵5. Hu HZ, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kawada M, Lee LY, Wood JD, and Zhu MX (2004) 2-Aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2 and TRPV3. J Biol Chem 279:35741-35748