TRPV6 channel

Channel name TRPV61,2,3
Description Calcium-selective TRP channel
Other names ECaC2, CaT1
Molecular information Human unigene: Hs0.302740, chr. 7q33–34
Mouse unigene: Mm0.296889, chr. 6
Associated subunits Not established
Functional assays Patch-clamp, calcium imaging
Current Inwardly rectifying, calcium-sensitive cation current
Conductance 42–58pS in calcium-free solution
Erev in saline solution >50 mV
Ion selectivity Ca2+ > Ba2+ > Sr2+ > Mn2+; PNa/PCa = 1:130
Activation Constitutively active
Inactivation Not established
Activators None
Gating inhibitors None
Blockers Ruthenium red (5 μM), La3+
Radioligands None
Channel distribution Kidney, intestine
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments One of only two known TRP channels (with TRPV5) that is relatively highly Ca2+-selective
  • chr., chromosome.

  • 1. Yue L, Peng JB, Hediger MA, and Clapham DE (2001) CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature (Lond) 410:705-709

  • 2. Bodding M and Flockerzi V (2004) Ca2+ dependence of the Ca2+-selective TRPV6 channel. J Biol Chem 279:36546-36552

  • 3. Lambers TT, Weidema AF, Nilius B, Hoenderop JG, and Bindels RJ (2004) Regulation of the mouse epithelial Ca2+ channel TRPV6 by the Ca2+-sensor calmodulin. J Biol Chem 279:28855-28861