TRPV6 channel
| Channel name | TRPV61,2,3 |
| Description | Calcium-selective TRP channel |
| Other names | ECaC2, CaT1 |
| Molecular information | Human unigene: Hs0.302740, chr. 7q33–34 |
| Mouse unigene: Mm0.296889, chr. 6 | |
| Associated subunits | Not established |
| Functional assays | Patch-clamp, calcium imaging |
| Current | Inwardly rectifying, calcium-sensitive cation current |
| Conductance | 42–58pS in calcium-free solution |
| Erev in saline solution >50 mV | |
| Ion selectivity | Ca2+ > Ba2+ > Sr2+ > Mn2+; PNa/PCa = 1:130 |
| Activation | Constitutively active |
| Inactivation | Not established |
| Activators | None |
| Gating inhibitors | None |
| Blockers | Ruthenium red (5 μM), La3+ |
| Radioligands | None |
| Channel distribution | Kidney, intestine |
| Physiological functions | Not established |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | One of only two known TRP channels (with TRPV5) that is relatively highly Ca2+-selective |
chr., chromosome.
↵1. Yue L, Peng JB, Hediger MA, and Clapham DE (2001) CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature (Lond) 410:705-709
↵2. Bodding M and Flockerzi V (2004) Ca2+ dependence of the Ca2+-selective TRPV6 channel. J Biol Chem 279:36546-36552
↵3. Lambers TT, Weidema AF, Nilius B, Hoenderop JG, and Bindels RJ (2004) Regulation of the mouse epithelial Ca2+ channel TRPV6 by the Ca2+-sensor calmodulin. J Biol Chem 279:28855-28861