TRPM1 channel
| Channel name | TRPM11,2,3,4 |
| Description | Putative melastatin TRP channel |
| Other names | Melastatin, LTRPC1 |
| Molecular information | Human unigene: Hs0.155942, chr. 15q13-q14 |
| Mouse unigene: Mm0.38875, chr. 7 | |
| Associated subunits | Short transcript of M1 (MLSN-S) |
| Functional assays | Calcium imaging |
| Current | Not established |
| Conductance | Not established |
| Ion selectivity | Ca2+ permeable |
| Activation | Not established |
| Inactivation | Not established |
| Activators | None |
| Blockers | None |
| Gating inhibitors | None |
| Radioligands | None |
| Channel distribution | Eye, melanocytes |
| Physiological functions | Not established |
| Mutations and pathophysiology | Down-regulated in melanoma |
| Pharmacological significance | Alternatively spliced form suppresses calcium entry though HEK cells expressing full-length melastatin |
| Comments | TRPM1 is the founding member of the TRPM family; alternatively spliced long and short forms exist; the two forms interact |
chr., chromosome; HEK, human embryonic kidney.
↵1. Hunter JJ, Shao J, Smutko JS, Dussault BJ, Nagle DL, Woolf EA, Holmgren LM, Moore KJ, and Shyjan AW (1998) Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1). Genomics 54:116-123
↵2. Duncan LM, Deeds J, Cronin FE, Donovan M, Sober AJ, Kauffman M, and McCarthy JJ (2001) Melastatin expression and prognosis in cutaneous malignant melanoma. J Clin Oncol 19:568-576
↵3. Fang D and Setaluri V (2000) Expression and up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells. Biochem Biophys Res Commun 279:53-61
↵4. Xu XZ, Moebius F, Gill DL, and Montell C (2001) Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc Natl Acad Sci USA 98:10692-10697