TRPM1 channel

Channel name TRPM11,2,3,4
Description Putative melastatin TRP channel
Other names Melastatin, LTRPC1
Molecular information Human unigene: Hs0.155942, chr. 15q13-q14
Mouse unigene: Mm0.38875, chr. 7
Associated subunits Short transcript of M1 (MLSN-S)
Functional assays Calcium imaging
Current Not established
Conductance Not established
Ion selectivity Ca2+ permeable
Activation Not established
Inactivation Not established
Activators None
Blockers None
Gating inhibitors None
Radioligands None
Channel distribution Eye, melanocytes
Physiological functions Not established
Mutations and pathophysiology Down-regulated in melanoma
Pharmacological significance Alternatively spliced form suppresses calcium entry though HEK cells expressing full-length melastatin
Comments TRPM1 is the founding member of the TRPM family; alternatively spliced long and short forms exist; the two forms interact
  • chr., chromosome; HEK, human embryonic kidney.

  • 1. Hunter JJ, Shao J, Smutko JS, Dussault BJ, Nagle DL, Woolf EA, Holmgren LM, Moore KJ, and Shyjan AW (1998) Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1). Genomics 54:116-123

  • 2. Duncan LM, Deeds J, Cronin FE, Donovan M, Sober AJ, Kauffman M, and McCarthy JJ (2001) Melastatin expression and prognosis in cutaneous malignant melanoma. J Clin Oncol 19:568-576

  • 3. Fang D and Setaluri V (2000) Expression and up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells. Biochem Biophys Res Commun 279:53-61

  • 4. Xu XZ, Moebius F, Gill DL, and Montell C (2001) Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc Natl Acad Sci USA 98:10692-10697