K2P6.1 channels

Channel name K2P6.1
Description Two-pore domain potassium channel subunit; open rectifier
Other names KCNK6, TWIK-2, TOSS
Molecular information Human: 313aa,1 NM_004823, chr0.19q13-1,2 KCNK6, GeneID: 9424, PMID: 103590731
Rat: 313aa, NM_053806, kcnk6
Mouse: not cloned
Associated subunits Not established
Functional assays Electrophysiological
Current Open rectifier3,4
Conductance <5pS
Ion selectivity Not established
Activation See “Comments”
Inactivation See “Comments”
Activators Arachidonic acid
Gating inhibitors None
Blockers Ba2+ (100 μM), quinidine (100 mM), volatile anesthetics
Radioligands None
Channel distribution Pancreas, placenta, heart (see “Comments”)
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments Activation and deactivation with voltage steps seem to be instantaneous; displays time-dependent inactivation at depolarized potentials4; the rat variant has been reported to be widely expressed (including brain, lung, kidney, liver, spleen, heart, esophagus, stomach, colon, and skeletal muscle)
  • aa, amino acids; chr., chromosome; TOSS, TWIK-originated similarity sequence.

  • 1. Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, Holmes D, Saganich M, Rudy B, Artman M, and Coetzee WA (1999) Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit. FEBS Lett 450:191-196

  • 2. Gray AT, Kindler CH, Sampson ER, and Yost CS (1999) Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. Cytogenet Cell Genet 84:190-191

  • 3. Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, and Yost CS (1999) TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. J Biol Chem 274:7887-7892

  • 4. Patel AJ, Maingret F, Magnone V, Fosset M, Lazdunski M, and Honoré E (2000) TWIK-2, an inactivating 2P domain K+ channel. J Biol Chem 275:28722-28730