K2P7.1 channels
| Channel name | K2P7.1 |
| Description | Two-pore domain potassium channel subunit |
| Other names | KCNK7, kcnk8 (see “Comments”) |
| Molecular information | Human: 307aa (see “Comments”), NM_033347, chr0.11q13, KCNK7, GeneID:10089, PMID: 102069911 |
| Rat: not cloned | |
| Mouse: 335aa, NM_010609, chr. 19,2B, kcnk8 (see “Comments”)1,2 | |
| Associated subunits | Not established |
| Functional assays | Electrophysiological |
| Current | Not established (see “Comments”) |
| Conductance | Not established |
| Ion selectivity | Not established |
| Activation | Not established |
| Inactivation | Not established |
| Activators | None |
| Gating inhibitors | None |
| Blockers | None |
| Radioligands | None |
| Channel distribution | Brain (human), retina (mouse) |
| Physiological functions | Not established |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
| Comments | The product of this gene has not yet been shown to form a functional channel; five splice variants have been identified in human; the mouse isolate was cited as kcnk6 and then kcnk8 but is now called K2P7 due to its homology and syntenic location to human KCNK72 |
aa, amino acids; chr., chromosome.
↵1. Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, and Lazdunski M (1999) Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. J Biol Chem 274:11751-11760
↵2. Bockenhauer D, Nimmakayalu MA, Ward DC, Goldstein SAN, and Gallagher PG (2000) Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2P domain potassium channels. Gene 261:365-372