K2P7.1 channels

Channel name K2P7.1
Description Two-pore domain potassium channel subunit
Other names KCNK7, kcnk8 (see “Comments”)
Molecular information Human: 307aa (see “Comments”), NM_033347, chr0.11q13, KCNK7, GeneID:10089, PMID: 102069911
Rat: not cloned
Mouse: 335aa, NM_010609, chr. 19,2B, kcnk8 (see “Comments”)1,2
Associated subunits Not established
Functional assays Electrophysiological
Current Not established (see “Comments”)
Conductance Not established
Ion selectivity Not established
Activation Not established
Inactivation Not established
Activators None
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Brain (human), retina (mouse)
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments The product of this gene has not yet been shown to form a functional channel; five splice variants have been identified in human; the mouse isolate was cited as kcnk6 and then kcnk8 but is now called K2P7 due to its homology and syntenic location to human KCNK72
  • aa, amino acids; chr., chromosome.

  • 1. Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, and Lazdunski M (1999) Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. J Biol Chem 274:11751-11760

  • 2. Bockenhauer D, Nimmakayalu MA, Ward DC, Goldstein SAN, and Gallagher PG (2000) Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2P domain potassium channels. Gene 261:365-372