TRPM3 channel
| Channel name | TRPM31,2,3 |
| Description | Melastatin-related channel |
| Other names | hKIAA1616, LTRPC3 |
| Molecular information | Human unigene: Hs0.47288, chr. 9q21.11 |
| Mouse unigene: Mm0.124567, chr. 19 B | |
| Associated subunits | Not established |
| Functional assays | Patch-clamp, calcium imaging |
| Current | near linear I–V |
| Conductance | 83pS (140 mM symmetrical Na) |
| Ion selectivity | PNa/PCa ∼0.6 nonselective cationic |
| Activation | Constitutive, enhanced by hypo-osmolarity, sphingolipids |
| Inactivation | Independent of [Ca2+]i |
| Activators | Sphingolipids |
| Gating inhibitors | None |
| Blockers | Gd3+ (100 μM), insensitive to ruthenium red (1 μM) |
| Radioligands | None |
| Channel distribution | Widely expressed, kidney, brain |
| Physiological functions | Ca2+ absorption in renal collecting tubule |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
chr., chromosome.
↵1. Grimm C, Kraft R, Sauerbruch S, Schultz G, and Harteneck C (2003) Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem 278:21493-21501
↵2. Lee N, Chen J, Sun L, Wu S, Gray KR, Rich A, Huang M, Lin JH, Feder JN, Janovitz EB, et al. (2003) Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3) J Biol Chem 278:20890-20897
↵3. Grimm C, Kraft R, Schultz G, and Harteneck C (2004) Activation of the melastatin-related cation channel TRPM3 by d-erythro-sphingosine. Mol Pharmacol 67:798-805