TRPM3 channel

Channel name TRPM31,2,3
Description Melastatin-related channel
Other names hKIAA1616, LTRPC3
Molecular information Human unigene: Hs0.47288, chr. 9q21.11
Mouse unigene: Mm0.124567, chr. 19 B
Associated subunits Not established
Functional assays Patch-clamp, calcium imaging
Current near linear I–V
Conductance 83pS (140 mM symmetrical Na)
Ion selectivity PNa/PCa ∼0.6 nonselective cationic
Activation Constitutive, enhanced by hypo-osmolarity, sphingolipids
Inactivation Independent of [Ca2+]i
Activators Sphingolipids
Gating inhibitors None
Blockers Gd3+ (100 μM), insensitive to ruthenium red (1 μM)
Radioligands None
Channel distribution Widely expressed, kidney, brain
Physiological functions Ca2+ absorption in renal collecting tubule
Mutations and pathophysiology Not established
Pharmacological significance Not established
  • chr., chromosome.

  • 1. Grimm C, Kraft R, Sauerbruch S, Schultz G, and Harteneck C (2003) Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem 278:21493-21501

  • 2. Lee N, Chen J, Sun L, Wu S, Gray KR, Rich A, Huang M, Lin JH, Feder JN, Janovitz EB, et al. (2003) Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3) J Biol Chem 278:20890-20897

  • 3. Grimm C, Kraft R, Schultz G, and Harteneck C (2004) Activation of the melastatin-related cation channel TRPM3 by d-erythro-sphingosine. Mol Pharmacol 67:798-805