TRPM6 channel

Channel name TRPM61,2,3,4
Description Channel-kinase TRP channel
Other names ChaK2
Molecular information Human unigene: Hs0.272225, chr. 9q21.13
Mouse unigene: Mm0.215171, chr. 19 B
Associated subunits Not established
Functional assays Patch-clamp, calcium imaging
Current Steeply outward rectifying >0 mV
Conductance Not established
Ion selectivity Nonselective cationic, Mg2+ permeant
Activation Not established
Inactivation Not established
Activators None
Gating inhibitors None
Blockers Ruthenium red
Radioligands None
Channel distribution Widely distributed, kidney, gastrointestinal tract
Physiological functions Renal and gastrointestinal Mg2+ uptake
Mutations and pathophysiology Human hypomagnesemia with secondary hypocalcemia (HGH)
Pharmacological significance Not established
Comments Contains a protein kinase on its C terminus as part of the protein (chanzyme); currently difficult to separate from TRPM7 current
  • chr., chromosome.

  • 1. Ryazanova LV, Pavur KS, Petrov N, Dorovkov MV, and Ryazanov AG (2001) Novel type of signaling molecules: protein kinases covalently linked with ion channels. Mol Biol 35:271-283

  • 2. Schlingmann KP, Weber S, Peters M, Niemann Nejsum L, Vitzthum H, Klingel K, Kratz M, Haddad E, Ristoff E, Dinour D, et al. (2002) Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 31:166-170

  • 3. Walder RY, Landau D, Meyer P, Shalev H, Tsolia M, Borochowitz Z, Boettger MB, Beck GE, Englehardt RK, Carmi R, et al. (2002) Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet 31:171-174

  • 4. Voets T, Nilius B, Hoefs S, van der Kemp AW, Droogmans G, Bindels RJ, and Hoenderop JG (2004) TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem 279:19-25