TRPM6 channel
| Channel name | TRPM61,2,3,4 |
| Description | Channel-kinase TRP channel |
| Other names | ChaK2 |
| Molecular information | Human unigene: Hs0.272225, chr. 9q21.13 |
| Mouse unigene: Mm0.215171, chr. 19 B | |
| Associated subunits | Not established |
| Functional assays | Patch-clamp, calcium imaging |
| Current | Steeply outward rectifying >0 mV |
| Conductance | Not established |
| Ion selectivity | Nonselective cationic, Mg2+ permeant |
| Activation | Not established |
| Inactivation | Not established |
| Activators | None |
| Gating inhibitors | None |
| Blockers | Ruthenium red |
| Radioligands | None |
| Channel distribution | Widely distributed, kidney, gastrointestinal tract |
| Physiological functions | Renal and gastrointestinal Mg2+ uptake |
| Mutations and pathophysiology | Human hypomagnesemia with secondary hypocalcemia (HGH) |
| Pharmacological significance | Not established |
| Comments | Contains a protein kinase on its C terminus as part of the protein (chanzyme); currently difficult to separate from TRPM7 current |
chr., chromosome.
↵1. Ryazanova LV, Pavur KS, Petrov N, Dorovkov MV, and Ryazanov AG (2001) Novel type of signaling molecules: protein kinases covalently linked with ion channels. Mol Biol 35:271-283
↵2. Schlingmann KP, Weber S, Peters M, Niemann Nejsum L, Vitzthum H, Klingel K, Kratz M, Haddad E, Ristoff E, Dinour D, et al. (2002) Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 31:166-170
↵3. Walder RY, Landau D, Meyer P, Shalev H, Tsolia M, Borochowitz Z, Boettger MB, Beck GE, Englehardt RK, Carmi R, et al. (2002) Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet 31:171-174
↵4. Voets T, Nilius B, Hoefs S, van der Kemp AW, Droogmans G, Bindels RJ, and Hoenderop JG (2004) TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem 279:19-25