TRPC1 channel

Channel name TRPC11,2,3,4,5,6,7,8
Description Nonselective cation channel subunit
Other names TRP1
Molecular information Human unigene: Hs0.250687, chr. 3q22–3q24
Mouse unigene: Mm0.149633
Associated subunits TRPC4, TRPC5 (TRPC3–embryo), calmodulin, IP3Rs, caveolin-1, Gq/11, PMCA, mGluR1
Functional assays Patch-clamp, calcium imaging
Current Outwardly rectifying when coexpressed with TRPC4 and TRPC5
Conductance Not established
Ion selectivity PNa/PCa ∼1:1 (when coexpressed with TRPC4 and TRPC5)5
Activation Stretch?
Inactivation Not established
Activators Recording of Gq-coupled receptor (heteromer TRPC1/TRPC5), whole cell current, augmented store-operated influx as presumed homomer; no direct agonists identified, gated in response to stimulation of the Gq-coupled receptors, augmented by La3+ (heteromer of TRPC1 with TRPC4 or TRPC5)5; it has been proposed that the mGluR1-evoked slow EPSC is mediated by the TRPC1 cation channel; TRPC1 is expressed in perisynaptic regions of the cerebellar parallel fiber-Purkinje cell synapse and may be physically associated with mGluR16
Gating inhibitors None
Blockers Inhibited by 80 μM 2-APB (heteromer) and Gd3+
Radioligands None
Channel distribution Widely expressed; highest levels in brain, heart, kidney, lung, skeletal muscle, prostate, skin testis, ovaries
Physiological functions Putative role in receptor-mediated, Ca2+-dependent secretion and contraction
Mutations and pathophysiology Not established
Pharmacological significance Involved in Ca2+ entry induced by phospholipid hydrolysis (PI response) and Ca2+ store depletion
Comments Splice variants in human and mouse
  • chr., chromosome; PMCA, plasma membrane calcium pump; EPSC, excitatory postsynaptic current; PI, phosphatidylinositol.

  • 1. Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stettten G, and Montell C (1995) TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci USA 92:9652-9656

  • 2. Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, and Birnbaumer L (1996) trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell 85:661-671

  • 3. Zitt C, Zobel A, Obukhov AG, Harteneck C, Kalkbrenner F, Luckhoff A, and Schultz G (1996) Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. Neuron 16:1189-1196

  • 4. Lintschinger B, Balzer-Geldsetzer M, Baskaran T, Graier WF, Romanin C, Zhu MX, and Groschner K (2000) Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels. J Biol Chem 275:27799-27805

  • 5. Strübing C, Krapivinsky G, Krapivinsky L, and Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645-655

  • 6. Xu XZ, Li HS, Guggino WB, and Montell C (1997) Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell 89:1155-1164

  • 7. Brazer SC, Singh BB, Liu X, Swaim W, and Ambudkar IS (2003) Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1. J Biol Chem 278:27208-27215

  • 8. Kim SJ, Kim YS, Yuan JP, Petralia RS, Worley PF, and Linden DJ (2003) Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature (Lond) 426:285–291</.>