TRPP2 channel
| Channel name | TRPP21 |
| Description | Nonselective cation channel subunit |
| Other names | PKD2L1, TRPP3 |
| Molecular information | Human unigene: Hs0.159241, chr. 10q24 |
| Mouse unigene: Mm.308481 | |
| Associated subunits | Not established |
| Functional assays | Patch-clamp, calcium imaging |
| Current | Near linear |
| Conductance | 137pS in 100 mM Na+ |
| Ion selectivity | PNa/PCa ∼ 1:4 |
| Inactivation | Not established |
| Activators | 1 μM [Ca2+]i |
| Gating inhibitors | None |
| Blockers | Not established |
| Radioligands | None |
| Channel distribution | Eye, kidney, testis |
| Physiological functions | Involved in kidney and retinal development based on krd (P3–/–mouse) |
| Mutations and pathophysiology | Not established |
| Comments | Electrophysiological properties not firmly established; note that the nomenclature is not settled by HUGO—here we have grouped only the 6TM subtypes as TRPPs and left the longer (11TMs such as PKD1) polycystins out of the classification |
chr., chromosome; PKD2L1, polycystic kidney disease protein 2-like protein 1.
↵1. Nomura H, Turco AE, Pei Y, Kalaydjieva L, Schiavello T, Weremowicz S, Ji W, Morton CC, Meisler M, Reeders ST, et al. (1998) Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. J Biol Chem 273:25967-25973