TRPP2 channel

Channel name TRPP21
Description Nonselective cation channel subunit
Other names PKD2L1, TRPP3
Molecular information Human unigene: Hs0.159241, chr. 10q24
Mouse unigene: Mm.308481
Associated subunits Not established
Functional assays Patch-clamp, calcium imaging
Current Near linear
Conductance 137pS in 100 mM Na+
Ion selectivity PNa/PCa ∼ 1:4
Inactivation Not established
Activators 1 μM [Ca2+]i
Gating inhibitors None
Blockers Not established
Radioligands None
Channel distribution Eye, kidney, testis
Physiological functions Involved in kidney and retinal development based on krd (P3–/–mouse)
Mutations and pathophysiology Not established
Comments Electrophysiological properties not firmly established; note that the nomenclature is not settled by HUGO—here we have grouped only the 6TM subtypes as TRPPs and left the longer (11TMs such as PKD1) polycystins out of the classification
  • chr., chromosome; PKD2L1, polycystic kidney disease protein 2-like protein 1.

  • 1. Nomura H, Turco AE, Pei Y, Kalaydjieva L, Schiavello T, Weremowicz S, Ji W, Morton CC, Meisler M, Reeders ST, et al. (1998) Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. J Biol Chem 273:25967-25973