TRPP3 channel
| Channel name | TRPP31 |
| Description | Nonselective cation channel subunit |
| Other names | PKD2L2, TRPP5 |
| Molecular information | Human unigene: Hs0.546413, chr. 19p13.3-p13.2 |
| Mouse unigene: Mm0.8356, chr. 8 | |
| Associated subunits | Not established |
| Functional assays | Patch-clamp, calcium imaging |
| Current | Not established |
| Conductance | 83pS in 100 mM Na+ |
| Ion selectivity | PNa/PCa ∼ 1 |
| Activation | Not established |
| Inactivation | Not established |
| Activators | [Ca2+]i? |
| Gating inhibitors | Not established |
| Blockers | Not established |
| Radioligands | Not established |
| Channel distribution | Near ubiquitous |
| Physiological functions | Role in sorting/transport in late endocytic pathway; defective in mucolipidosis type IV lysosomal storage disease |
| Mutations and pathophysiology | Not established |
| Comments | Electrophysiological properties not firmly established; note that the nomenclature is not settled by HUGO—here we have grouped only the 6TM subtypes as TRPPs and left the longer (11TMs such as PKD1) polycystins out of the classification |
chr., chromosome; PKD2L2, polycystic kidney disease protein 2-like protein 2.
↵1. Guo L, Schreiber TH, Weremowicz S, Morton CC, Lee C, and Zhou J (2000) Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Genomics 64:241-251