TRPP3 channel

Channel name TRPP31
Description Nonselective cation channel subunit
Other names PKD2L2, TRPP5
Molecular information Human unigene: Hs0.546413, chr. 19p13.3-p13.2
Mouse unigene: Mm0.8356, chr. 8
Associated subunits Not established
Functional assays Patch-clamp, calcium imaging
Current Not established
Conductance 83pS in 100 mM Na+
Ion selectivity PNa/PCa ∼ 1
Activation Not established
Inactivation Not established
Activators [Ca2+]i?
Gating inhibitors Not established
Blockers Not established
Radioligands Not established
Channel distribution Near ubiquitous
Physiological functions Role in sorting/transport in late endocytic pathway; defective in mucolipidosis type IV lysosomal storage disease
Mutations and pathophysiology Not established
Comments Electrophysiological properties not firmly established; note that the nomenclature is not settled by HUGO—here we have grouped only the 6TM subtypes as TRPPs and left the longer (11TMs such as PKD1) polycystins out of the classification
  • chr., chromosome; PKD2L2, polycystic kidney disease protein 2-like protein 2.

  • 1. Guo L, Schreiber TH, Weremowicz S, Morton CC, Lee C, and Zhou J (2000) Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Genomics 64:241-251