TRPML3 channel

Channel name TRPML31
Description Nonselective cation channel subunit
Other names MCOLN3, mucolipin 3
Molecular information Human unigene: Hs0.535239, chr. 1p22.3
Mouse unigene: Mm0.114683, chr. 3
Associated subunits Not established
Functional assays Patch-clamp, calcium imaging
Current Not established
Conductance Not established
Ion selectivity Not established
Activation Not established
Inactivation Not established
Activators Not established
Gating inhibitors Not established
Blockers Not established
Radioligands Not established
Channel distribution Widely expressed
Physiological functions Hair cell, stereocilia maturation
Mutations and pathophysiology Not established
Comments Va
  • chr., chromosome; Va, Varitint-waddler mouse.

  • 1. Di Palma F, Belyantseva IA, Kim HJ, Vogt TF, Kachar B, and Noben-Trauth K (2002) Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. Proc Natl Acad Sci USA 99:14994-14999