TRPC2 channel
| Channel name | TRPC21,2,3,4,5,6,7 |
| Description | Mouse pheromone channel |
| Other names | mTrp2 (in mouse) |
| Molecular information | Human unigene: Hs0.131910 probable pseudogene, chr. 0.7 |
| Mouse unigene: Mm0.292904, chr. 11p15.4-p15.3 | |
| Associated subunits | Not established |
| Functional assays | Patch-clamp |
| Current | Near linear, nonselective cation conductance |
| Conductance | 42pS (symmetrical 140 Na+)7 |
| Ion selectivity | Cation nonselective |
| Activation | Indirect via pheromone receptors |
| Inactivation | Not established |
| Activators | DAGs (10–100 μM) |
| Gating inhibitors | None |
| Blockers | None |
| Radioligands | None |
| Channel distribution | Vomeronasal organ, testis, heart, kidney, brain, sperm |
| Physiological functions | Sensory transduction in vomeronasal organ, possible role in acrosome reaction in sperm |
| Mutations and pathophysiology | TRPC2-deficient mice display abnormal mating behavior |
| Pharmacological significance | Candidate for mammalian pheromone sensory signaling |
| Comments | Human and bovine versions are likely to be pseudogenes2; the murine channel is expressed as multiple splice variants |
chr., chromosome.
↵1. Liman E, Corey DP, and Dulac C (1999) TRP2: a candidate transduction channel for mammalian pheromone sensory signaling. Proc Natl Acad Sci USA 96:5791-5796
↵2. Vannier B, Peyton M, Boulay G, Brown D, Qin N, Jiang M, Zhu X, and Birnbaumer L (1999) Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel. Proc Natl Acad Sci USA 96:2060-2064
↵3. Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, and Montell C (1995) TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci USA 92:9652-9656
↵4. Hofmann T, Schaefer M, Schultz G, and Gudermann T (2000) Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem J 351:115-122
↵5. Jungnickel MK, Marrero H, Birnbaumer L, Lemos JR, and Florman HM (2001) Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3. Nat Cell Biol 3:499-502
↵6. Stowers L, Holy TE, Meister M, Dulac C, and Koentges G (2002) Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science (Wash DC) 295:1493-1500
↵7. Lucas P, Ukhanov K, Leinders-Zufall T, and Zufall F (2003) A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 40:551-561