TRPC2 channel

Channel name TRPC21,2,3,4,5,6,7
Description Mouse pheromone channel
Other names mTrp2 (in mouse)
Molecular information Human unigene: Hs0.131910 probable pseudogene, chr. 0.7
Mouse unigene: Mm0.292904, chr. 11p15.4-p15.3
Associated subunits Not established
Functional assays Patch-clamp
Current Near linear, nonselective cation conductance
Conductance 42pS (symmetrical 140 Na+)7
Ion selectivity Cation nonselective
Activation Indirect via pheromone receptors
Inactivation Not established
Activators DAGs (10–100 μM)
Gating inhibitors None
Blockers None
Radioligands None
Channel distribution Vomeronasal organ, testis, heart, kidney, brain, sperm
Physiological functions Sensory transduction in vomeronasal organ, possible role in acrosome reaction in sperm
Mutations and pathophysiology TRPC2-deficient mice display abnormal mating behavior
Pharmacological significance Candidate for mammalian pheromone sensory signaling
Comments Human and bovine versions are likely to be pseudogenes2; the murine channel is expressed as multiple splice variants
  • chr., chromosome.

  • 1. Liman E, Corey DP, and Dulac C (1999) TRP2: a candidate transduction channel for mammalian pheromone sensory signaling. Proc Natl Acad Sci USA 96:5791-5796

  • 2. Vannier B, Peyton M, Boulay G, Brown D, Qin N, Jiang M, Zhu X, and Birnbaumer L (1999) Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel. Proc Natl Acad Sci USA 96:2060-2064

  • 3. Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, and Montell C (1995) TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci USA 92:9652-9656

  • 4. Hofmann T, Schaefer M, Schultz G, and Gudermann T (2000) Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem J 351:115-122

  • 5. Jungnickel MK, Marrero H, Birnbaumer L, Lemos JR, and Florman HM (2001) Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3. Nat Cell Biol 3:499-502

  • 6. Stowers L, Holy TE, Meister M, Dulac C, and Koentges G (2002) Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science (Wash DC) 295:1493-1500

  • 7. Lucas P, Ukhanov K, Leinders-Zufall T, and Zufall F (2003) A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 40:551-561