TRPC5 channel

Channel name TRPC51,2,3,4,5,6,7
Description TRP receptor-operated channel
Other names TRP5, CCE2
Molecular information Human unigene: Hs0.247868, chr. Xq23
Mouse unigene: Mm0.328378, chr. X
Associated subunits Forms heteromultimers with TRPC1 and TRPC4
Functional assays Patch-clamp, calcium imaging
Current Nonselective, double rectification
Conductance ∼38pS as homomer, ∼5pS as TRPC1/C5 heteromer
Ion selectivity PNa/PCa = 1:9,1 1:1.82
Activation Stimulation of Gq-coupled receptors, receptor tyrosine kinases
Inactivation Not established
Activators Activation of Gq-coupled receptors is known to activate TRPC5 current through activation of PLCγ; La3+ (100 μM) augments current
Gating inhibitors None
Blockers mM La3+, 2-APB
Radioligands None
Channel distribution Brain, lung, placenta, testis
Physiological functions Not established
Mutations and pathophysiology Not established
Pharmacological significance Not established
Comments Channel properties of heteromeric TRPC1/TRPC4 or TRPC1/TRPC5 are distinct from those of TRPC4 or TPRC5 homomers; rapid insertion of vesicles in growth cones; regulator of neurite morphology
  • chr., chromosome; RTK, receptor tyrosine kinase.

  • 1. Okada T, Shimizu S, Wakamori M, Maeda A, Kurosaki T, Takada N, Imoto K, and Mori Y (1998) Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J Biol Chem 273:10279-10287

  • 2. Schaefer M, Plant TD, Obukhov AG, Hofmann T, Gudermann T, and Schultz G (2000) Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem 275:17517-17526

  • 3. Strübing C, Krapivinsky G, Krapivinsky L, and Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645-655

  • 4. Strübing C, Krapivinsky G, Krapivinsky L, and Clapham DE (2003) Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem 278:39014-39019

  • 5. Bezzerides VJ, Ramsey IS, Greka A, Kotecha SA, and Clapham DE (2004) Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol 6:709-720

  • 6. Greka A, Navarro B, Oancea E, Duggan A, and Clapham DE (2003) TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci 6:837-845

  • 7. Lee YM, Kim BJ, Kim HJ, Yang DK, Zhu MH, Lee KP, So I, and Kim KW (2003) TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach. Am J Physiol Gastrointest Liver Physiol 284:G604-G616