TRPC7 channel

Channel name TRPC71,2
Description Cardiac TRP channel
Other names TRP7
Molecular information Human unigene: Hs0.283104, chr. 5q31.1
Mouse unigene: Mm0.62409, chr. 13 B2
Associated subunits TRPC3, TRPC6, calmodulin, FKBP12
Functional assays Patch-clamp, calcium imaging
Current Inwardly and outwardly rectifying, nonselective cation current
Conductance 50pS (0–100 mV); 25pS (–100 to 0 mV)
Ion selectivity PNa/PCa ∼1:1.9
Activation Sensitive to intracellular Ca2+
Inactivation Not established
Activators DAG and analogs (100 μM)
Gating inhibitors None
Blockers La3+ (100 μM), SKF96365 (25 μM), 0.1–0.4 mM [Ca2+]o
Radioligands None
Channel distribution Heart, lung, eye, brain, spleen, testis
Physiological functions Cation influx in response to Gq activation
Mutations and pathophysiology Not established
Pharmacological significance Extracellular ATP (possibly via purinergic receptors), modulated by intracellular calcium, PKC
  • chr., chromosome.

  • 1. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, et al. (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca2+-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274:27359-27370

  • 2. Shi J, Mori E, Mori Y, Mori M, Li J, Ito Y, and Inoue R (2004) Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cell. J Physiol 561:415-432