TRPC7 channel
| Channel name | TRPC71,2 |
| Description | Cardiac TRP channel |
| Other names | TRP7 |
| Molecular information | Human unigene: Hs0.283104, chr. 5q31.1 |
| Mouse unigene: Mm0.62409, chr. 13 B2 | |
| Associated subunits | TRPC3, TRPC6, calmodulin, FKBP12 |
| Functional assays | Patch-clamp, calcium imaging |
| Current | Inwardly and outwardly rectifying, nonselective cation current |
| Conductance | 50pS (0–100 mV); 25pS (–100 to 0 mV) |
| Ion selectivity | PNa/PCa ∼1:1.9 |
| Activation | Sensitive to intracellular Ca2+ |
| Inactivation | Not established |
| Activators | DAG and analogs (100 μM) |
| Gating inhibitors | None |
| Blockers | La3+ (100 μM), SKF96365 (25 μM), 0.1–0.4 mM [Ca2+]o |
| Radioligands | None |
| Channel distribution | Heart, lung, eye, brain, spleen, testis |
| Physiological functions | Cation influx in response to Gq activation |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Extracellular ATP (possibly via purinergic receptors), modulated by intracellular calcium, PKC |
chr., chromosome.
↵1. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K, et al. (1999) Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca2+-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem 274:27359-27370
↵2. Shi J, Mori E, Mori Y, Mori M, Li J, Ito Y, and Inoue R (2004) Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cell. J Physiol 561:415-432