CatSper2 channel

Channel name CatSper21
Description Putative voltage-gated calcium-selective ion channel subunit
Other names None
Molecular information Human unigene: Hs0.389181: AF411817; chr. 15q14; four splice variants
Mouse unigene: Mm0.271895: NM_153075; chr. 2E5
Associated subunits Not established
Functional assays Calcium imaging
Current Not established
Conductance Not established
Ion selectivity Putative Ca2+-permeant
Activation Putative voltage-gated
Inactivation Not established
Activators Not established
Gating inhibitors Not established
Blockers Not established
Radioligands None
Channel distribution Mature sperm cells
Physiological functions CatSper2 is essential for the hyperactivation of sperm motility, which is required for male fertility; CatSper2 has been implicated by linkage analysis in human asthenoteratozoospermia2
Mutations and pathophysiology Not established
Pharmacological significance Not established
  • chr., chromosome.

  • 1. Quill TA, Ren D, Clapham DE, and Garbers DL (2001) A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci USA 98:12527-12531

  • 2. Avidan N, Tamary H, Dgany O, Cattan D, Pariente A, Thulliez M, Borot N, Moati L, Barthelme A, Shalmon L, et al. (2003) CATSPER2, a human autosomal nonsyndromic male infertility gene. Eur J Hum Genet 11:497-502