CatSper2 channel
| Channel name | CatSper21 |
| Description | Putative voltage-gated calcium-selective ion channel subunit |
| Other names | None |
| Molecular information | Human unigene: Hs0.389181: AF411817; chr. 15q14; four splice variants |
| Mouse unigene: Mm0.271895: NM_153075; chr. 2E5 | |
| Associated subunits | Not established |
| Functional assays | Calcium imaging |
| Current | Not established |
| Conductance | Not established |
| Ion selectivity | Putative Ca2+-permeant |
| Activation | Putative voltage-gated |
| Inactivation | Not established |
| Activators | Not established |
| Gating inhibitors | Not established |
| Blockers | Not established |
| Radioligands | None |
| Channel distribution | Mature sperm cells |
| Physiological functions | CatSper2 is essential for the hyperactivation of sperm motility, which is required for male fertility; CatSper2 has been implicated by linkage analysis in human asthenoteratozoospermia2 |
| Mutations and pathophysiology | Not established |
| Pharmacological significance | Not established |
chr., chromosome.
↵1. Quill TA, Ren D, Clapham DE, and Garbers DL (2001) A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci USA 98:12527-12531
↵2. Avidan N, Tamary H, Dgany O, Cattan D, Pariente A, Thulliez M, Borot N, Moati L, Barthelme A, Shalmon L, et al. (2003) CATSPER2, a human autosomal nonsyndromic male infertility gene. Eur J Hum Genet 11:497-502