CNGA2 channels
| Channel name | CNGA21,2,3 |
| Description | Cyclic nucleotide-gated cation channel A subunit |
| Other names | CNG2, CNGa3, OCNC1 |
| Molecular information | Human: 664aa, NM_005140, NP_005131, chr. Xq27 |
| Rat: 664aa, NM_012928, NP_037060, chr. Xq37 | |
| Mouse: 664aa, NM_007724, NP_031750, chr. X A6 | |
| Associated subunits | CNGB1b, CNGA4 (olfactory CNG channel: 2 CNGA2: 1 CNGA4:1 CNGB1b) |
| Functional assays | Patch-clamp, calcium imaging |
| Current | Cyclic nucleotide-activated current |
| Conductance | 35pS (in calcium-free solution) |
| Ion selectivity | Ca2+ > K+ ∼ Na+ |
| Activation | Not established |
| Inactivation | Not established |
| Activators | cGMP > cAMP |
| Gating modifiers | Ca2+-calmodulin |
| Blockers | Pseudechetoxin |
| Radioligands | None |
| Channel distribution | Olfactory neurones, hippocampus, some other neurones |
| Physiological functions | Olfactory transduction |
| Mutations and pathophysiology | Not established in humans |
| Pharmacological significance | Not established |
aa, amino acids; chr., chromosome.
↵1. Dhallan RS, Yau KW, Schrader KA, and Reed RR (1990) Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature (Lond) 347:184-187
↵2. Ludwig J, Margalit T, Eismann E, Lancet D, and Kaupp UB (1990) Primary structure of cAMP-gated channel from bovine olfactory epithelium. FEBS Lett 270:24-29
↵3. Ruiz ML, London B, and Nadal-Ginard B (1996) Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart. J Mol Cell Cardiol 28:1453-1461