CNG4A channels

Channel name CNGA41,2
Description Cyclic nucleotide-gated cation channel A subunit
Other names CNG5, CNGa4, OCNC2, CNGB2
Molecular information Human: 575aa, XM_290552, XP_290552, chr. 11p15.4
Rat: 575aa, NM_053496, NP_445948, chr. 1q32
Mouse: 575aa, XM_145875, XP_145875, chr. 7 E3
Associated subunits CNGA2, CNGB1b
Functional assays When assembled with CNGA2 and CNGB1b subunits: patch-clamp, calcium imaging
Current Not functional on its own
Conductance Not established
Ion selectivity Not established
Activation Not established
Inactivation Not established
Activators None
Gating modifiers Ca2+-calmodulin (in native olfactory channel)
Blockers None
Radioligands None
Channel distribution Olfactory neurons, some central neurons
Physiological functions Modulatory subunit of native olfactory CNG channel: increases cAMP sensitivity and accelerates Ca2+-calmodulin-dependent odor adaptation
Mutations and pathophysiology Not established in humans
Pharmacological significance Not established
  • aa, amino acids; chr., chromosome.

  • 1. Bradley J, Li J, Davidson N, Lester HA, and Zinn K (1994) Heteromeric factory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc Natl Acad Sci USA 91:8890-8894

  • 2. Liman ER and Buck LB (1994) A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron 13:611-621