Protein/Gene | Alternative Names | Substrates | References |
---|---|---|---|
MRP1/ABCC1 | MRP; GS-X | Leukotriene C4; oxidized glutathione; vincristine; daunorubicin; etoposide; methotrexate; glutathione, glucuronide, and sulfate conjugates | Judlitschky et al. (1996); Loe et al. (1996); Keppler et al. (1997); Rappa et al. (1997); Loe et al. (1998); Hooijberg et al. (1999); Leslie et al. (2005) |
MRP2/ABCC2 | cMOAT; cMRP | Similar to MRP1; cisplatin; methotrexate | Jedlitschky et al. (1997); Evers et al. (1998); Suzuki and Sugiyama (1998); Cui et al. (1999); Hooijberg et al. (1999); Kawabe et al. (1999) |
MRP3/ABCC3 | MOAT-D | Monoanionic and conjugated bile acids; etoposide; methotrexate | Hirohashi et al. (2000); Zelcer et al. (2001); Meier and Stieger (2002) |
cMOAT2 | |||
MLP-2* | |||
MRP4/ABCC4 | MOAT-B | Cyclic nucleotides (cAMP, cGMP); nucleotide analogs (PMEA, azidothymidine-monophosphate); prostaglandins; methotrexate | Schuetz et al. (1999); Reid et al. (2003a,b); Wielinga et al. (2003) |
MRP5/ABCC5 | MOAT-C | Cyclic nucleotides (cAMP, cGMP); nucleotide analogs (PMEA, stavudine-monophosphate) | Jedlitschky et al. (2000); Wijnholds et al. (2000b); Wielinga et al. (2003); Reid et al. (2003a) |
SMRP | |||
MRP6/ABCC6 | MOAT- E; MLP-1a | Small peptides (BQ123); glutathione conjugates | Madon et al. (2000); Belinsky et al. (2002); Iliás et al. (2002) |
MRP7/ABCC10 | Estradiol-17 β-glucuronide; leukotriene C4; docetaxel | Chen et al. (2003); Hopper-Borge et al. (2004) | |
MRP8/ABCC11 | Nucleotide analogs (PMEA), DHEAS, fluoropyrimidines | Guo et al. (2003); Chen et al. (2005b) | |
MRP9/ABCC12 | N.A. | Bera et al. (2002) |
MOAT, multispecific organic anion transporter; N.A., not available; SMRP, short MRP; DHEAS, dehydroepiandrosterone 3-sulfate
↵ a The MLP-1 and MLP-2 proteins were subsequently identified as rat orthologs of MRP6 and MRP3, respectively