Subunit | Pharmacology | Effectors | References |
---|---|---|---|
Gαs | CTX, GTPγS, GDPβS | Adenylyl cyclase (activates) | McCudden et al. (2005) |
Gαi | PTX, GTPγS, GDPβS | Adenylyl cyclase (inhibits) | McCudden et al. (2005) |
Gαt | CTX, PTX, GTPγS, GDPβS | cGMP phosphodiesterase (activates) | Arshavsky et al. (2002); Margolskee (2002) |
Gαq | GTPγS, GDPβS | Phospholipase Cβ, Bruton's tyrosine kinase (activates) | Rhee (2001) |
Gα12 | GTPγS, GDPβS | p115RhoGEF, Hsp90 | Kozasa et al. (1998); Vaiskunaite et al. (2001) |
Gβγ | GIRK channels, phospholipase Cβ, adenylyl cyclase II, adenylyl cyclase IV (activates); rhodopsin kinases (recruits/activates); Cav2 calcium channels (inhibits) | Clapham and Neer (1997); Cabrera-Vera et al. (2003) |
CTX, cholera toxin; GTPγS, guanosine 5′-O-(3-thio)triphosphate; GDPβS, guanosine 5′-O-(2-thio)diphosphate; Hsp, heat shock protein; GIRK, Gβγ-regulated inwardly rectifying K+ channel