TABLE 18

Toxicity of rotenone and pyrethrins to houseflies: original data and computer-analyzed summary of results Modified from “Quantitative Analysis of Dose-Effect Relationships: The Combined Effects of Multiple Drugs or Enzyme Inhibitors,” Advances in Enzyme Regulation, volume 22, pp 27-55. Copyright 1984 with permission from Elsevier.

Original Dataa CompuSyn-Generated Resultsb
Compound or Mixture Concentration % Killc Dose-Effect Parameters Combination Index at: Dose-Reduction Index at:
m Dmr ED50 ED75 ED90 ED95 ED50 ED75 ED90 ED95
μg/ml
Rotenone (R) 0.1 26.0
0.15 47.5
0.20 67.5 2.626 0.151 0.907
0.25 81.5
0.35 89.5
Pyrethrins (P) 0.5 21.5
0.75 39.5
1.0 54.0 2.387 0.893 0.995
1.5 75.0
2.0 89.0
Rotenone + pyrethrins (1R:5P) 0.3 27.0 2.01 1.97 1.94 1.92
0.45 53.0
0.60 64.0 2.519 0.450 0.994 2.38 2.44 2.50 2.54
0.875 82.0 (0.075 + 0.375)
1.175 93.0 0.9176 0.9163 0.9155 0.9152
Rotenone + pyrethrins (1R:15P) 0.4 23.0 3.70 3.64 3.59 3.55
0.6 48.0
0.8 61.0 2.533 0.652 0.983 1.46 1.50 1.54 1.57
1.2 76.0 (0.041 + 0.611)
1.6 93.0 0.9543 0.9465 0.9274 0.9187
  • a Original data from Le Pelley and Sullivan (1936), retrieved and analyzed by Finney (1952), and analyzed by Chou and Talalay (1987)

  • b Further analyzed by CompuSyn (Chou and Martin, 2005). The full computer printouts are given in Supplemental Data Appendix III (http://pharmrev.aspetjournals.org/cgi/content/full/pr.58.3.10/DC1)

  • c Data for rotenone or pyrethrins alone were the average of two series of experiments