TABLE 20

Dose-effect relationship parameters of the seven drugs used singly against HIV-1 IIIB replication in MT4 cells The original data of Chou and Zhu (1997) were analyzed by CalcuSyn (Chou and Hayball, 1997). The dose-effect relationship parameters for potency, shape (sigmoidicity), and conformity are represented by Dm, m, and r, respectively, where Dm (EC50) is the x-intercept (antilog), m is the slope of the median-effect plot that signifies the shape of the dose-effect curve (m = 1, > 1, and < 1 indicate hyperbolic, sigmoidal, and negative sigmoidal curve, respectively), and r is the linear correlation coefficient of the median-effect plot (Chou, 1976, 1991). The ranges of values given are the mean of two separate experiments; each experiment consists of seven concentrations for each drug.

Drugs Parameters
Dmamr
μM
AZT 0.00109 ± 0.00005 2.535 ± 0.0093 0.983 ± 0.001
DDI 2.743 ± 0.0245 1.929 ± 0.066 0.963 ± 0.001
DDC 0.1235 ± 0.0396 2.111 ± 0.113 0.983 ± 0.007
D4T 0.0142 ± 0.0015 2.458 ± 0.267 0.997 ± 0.001
IFN 0.0616 ± 0.0212 1.317 ± 0.249 0.989 ± 0.001
NEV 0.0568 ± 0.0033 2.406 ± 0.022 0.991 ± 0.006
ABT-538 0.0073 ± 0.0009 3.157 ± 0.299 0.974 ± 0.004
  • a The IC50 concentration (Dm) for each drug was in μM except for IFN, which was in kU/ml