TABLE 23

Typical example of changes in DRI values and their relationship to CI values in two- to five-drug combinations

Drug Combinations DRIa Values at: CIb Values at:
EC50 EC75 EC90 EC95 EC50 EC75 EC90 EC95
AZT + 3.87 3.85 3.83 3.82 0.455 0.451 0.446 0.444
NEV (1:40) 5.09 5.24 5.40 5.50
AZT + 5.43 5.12 4.89 4.74
NEV + 7.08 6.97 6.86 6.79 0.368 0.371 0.377 0.381
IFN (1:40:16) 24.36 30.76 38.90 45.57
AZT + 3.80 4.14 4.33 4.56
NEV + 5.06 5.57 6.14 6.55 0.602 0.574 0.548 0.532
ABT-538 (1:40:4) 6.87 6.61 6.38 6.20
AZT + 6.0 6.0 6.0 6.05
NEV + 7.81 8.16 8.52 8.79 0.426 0.420 0.418 0.416
ABT-538 + 10.61 9.68 8.87 8.33
IFN (1:40:4:16) 26.89 36.00 48.26 58.93
AZT + 5.18 5.80 6.29 6.62
NEV + 6.99 7.84 8.79 9.51
ABT-538 + 9.50 9.28 9.13 9.00 0.609 0.539 0.485 0.455
IFN + 23.95 34.65 49.83 63.78
DDI (1:40:4:16:1600) 7.90 9.77 12.09 13.97
  • a The DRI provides a measure of how much (fold) the dose of each drug in a synergistic combination may be reduced at a given effect level compared with the doses of each drug alone. The relationship of CI and DRI is depicted in eq. 16

  • b CI values are obtained from Tables 21 and 22