TABLE 7

Dose-effect relationship based on the median-effect equation for the first- and higher-order systems, using the assigned m and Dm values to calculate the dose, Dx, for different effect, (fa)xEquation 8: (D)x = Dm [(fa)/(1 - fa)]1/m, where x is the fractional inhibition as specified by fa = (fa)x. The numbers in bold are used in Fig. 11, and the symbols correspond to the same symbols used in Fig. 11.

Assigned Dm Value for Potency Assigned m value for Shape Calculated Dose (D)x in μM at:
(D)0.1 for fa = 0.1 (D)0.2 for fa = 0.2 (D)0.4 for fa = 0.4 (D)0.5 for fa = 0.5 (D)0.6 for fa = 0.6 (D)0.8 for fa = 0.8 (D)0.9 for fa = 0.9
0.5 μM m = 1 0.05555 0.125 0.3333 0.5 (○) 0.75 2.0 4.5
m = 3 0.2404 0.315 0.4368 0.5 0.5724 0.7937 1.040
m = 5 0.3222 0.3789 0.4611 0.5 0.5422 0.6598 0.7759
1 μM m = 1 (○) 0.11111 (○) 0.25 (○) 0.6666 (○) 1.0 (□) 1.5 (○) 4.0 (○) 9.0 (○)
m = 3 (□) 0.48075 (□) 0.630 (□) 0.8736 (□) 1.0 (□) 1.1447 (□) 1.5874 (□) 2.0801 (□)
m = 5 (▵) 0.6444 (▵) 0.7579 (▵) 0.9221 (▵) 1.0 (▵) 1.0845 (▵) 1.3195 (▵) 1.5518 (▵)
2 μM m = 1 0.2222 0.5 1.3333 2.0 (▵) 3.0 8.0 18.0
m = 3 0.9615 1.260 1.747 2.0 2.2894 3.1748 4.1602
m = 5 1.2888 1.5157 1.8442 2.0 2.1689 2.6390 3.1037
4 μM m = 1 0.4444 1.0 2.666 4.0 (▿) 6.0 16.0 36.0
m = 3 1.9230 2.520 3.494 4.0 4.5788 6.3496 8.320
m = 5 2.5776 3.0314 3.688 4.0 4.3379 5.2780 6.2074
6 μM m = 1 0.6666 1.5 4.0 6.0 (⋄) 9.0 24.0 54.0
m = 3 2.8845 3.780 5.241 6.0 6.8683 9.5244 12.480
m = 5 3.8664 4.547 5.5326 6.0 6.5068 7.9170 9.3111
8 μM m = 1 0.8888 2.0 5.333 8.0 (×) 12.0 32.0 72.0
m = 3 3.6980 5.040 6.989 8.0 9.1577 12.699 16.641
m = 5 5.1552 6.0629 7.377 8.0 8.6756 10.556 12.4148
16 μM m = 1 1.7777 4.0 10.666 16.0 (+) 24.0 64.0 144.0
m = 3 7.3960 10.080 13.977 16.0 18.315 25.398 33.281
m = 5 10.310 12.126 14.754 16.0 17.352 21.112 24.8295