TABLE 5

A proposed experimental design showing the outlay of dose range and dose density of two drugs for drug combination analysis Modified from “Quantitation of Synergism and Antagonism of Two or More Drugs by Computerized Analysis,” Chou TC, in Synergism and Antagonism in Chemotherapy (Chou TC and Rideout DC eds) pp 223–244. Copyright 1991 with permission from Elsevier.

Drug 1
0 0.25 × (ED50)1 0.5 × (ED50)1 (ED50)1 2 × (ED50)1 4 × (ED50)1
0 Control (fa)1 (fa)1 (fa)1 (fa)1 (fa)1
(fa)0
0.25 × (ED50)2 (fa)2 (fa)1,2
Drug 2 0.5 × (ED50)2 (fa)2 (fa)1,2
(ED50)2 (fa)2 (fa)1,2
2 × (ED50)2 (fa)2 (fa)1,2
4 × (ED50)2 (fa)2 (fa)1,2