TABLE 1

Human nuclear receptors

Names Nomenclature Ligand
TRα NR1A1 Thyroid hormones
TRβ NR1A2 Thyroid hormones
RARα NR1B1 Retinoic acid
RARβ NR1B2 Retinoic acid
RARγ NR1B3 Retinoic acid
PPARα NR1C1 Fatty acids, leukotriene B4, fibrates
PPARβ NR1C2 Fatty acids
PPARγ NR1C3 Fatty acids, prostaglandin J2, thiazolidinediones
Rev-erbα NR1D1 Orphan
Rev-erbβ NR1D2 Orphan
RORα NR1F1 Cholesterol, cholesteryl sulfate
RORβ NR1F2 Retinoic acid
RORγ NR1F3 Orphan
LXRα NR1H3 Oxysterols, T0901317, GW3965
LXRβ NR1H2 Oxysterols, T0901317, GW3965
FXRα NR1H4 Bile acids, fexaramine
FXRβa NR1H5 Lanosterol
VDR NR1I1 Vitamin D, 1,25-dihydroxyvitamin D3
PXR NR1I2 Xenobiotics, 16α-cyanopregnenolone
CAR NR1I3 Xenobiotics, phenobarbital
HNF4α NR2A1 Orphan
HNF4γ NR2A2 Orphan
RXRα NR2B1 Retinoic acid
RXRβ NR2B2 Retinoic acid
RXRγ NR2B3 Retinoic acid
TR2 NR2C1 Orphan
TR4 NR2C2 Orphan
TLL NR2E2 Orphan
PNR NR2E3 Orphan
COUP-TFI NR2F1 Orphan
COUP-TFII NR2F2 Orphan
EAR2 NR2F6 Orphan
ERα NR3A1 Estradiol-17β, tamoxifen, raloxifene
ERβ NR3A2 Estradiol-17β, various synthetic compounds
ERR α NR3B1 Orphan
ERRβ NR3B2 DES, 4-OH tamoxifen
ERRγ NR3B3 DES, 4-OH tamoxifen
GR NR3C1 Cortisol, dexamethasone, RU486
MR NR3C2 Aldosterone, spirolactone
PR NR3C3 Progesterone, medroxyprogesterone acetate, RU486
AR NR3C4 Testosterone, flutamide
NGFI-B NR4A1 Orphan
NURR1 NR4A2 Orphan
NOR1 NR4A3 Orphan
SF1 NR5A1 Orphan
LRH-1 NR5A2 Orphan
GCNF NR6A1 Orphan
DAX-1 NR0B1 Orphan
SHP NR0B2 Orphan
  • a FXRβ is a pseudogene in human but is a functional lanosterol receptor in mouse (Robinson-Rechavi et al., 2001; Otte et al., 2003)