Names | Nomenclature | Ligand |
---|---|---|
TRα | NR1A1 | Thyroid hormones |
TRβ | NR1A2 | Thyroid hormones |
RARα | NR1B1 | Retinoic acid |
RARβ | NR1B2 | Retinoic acid |
RARγ | NR1B3 | Retinoic acid |
PPARα | NR1C1 | Fatty acids, leukotriene B4, fibrates |
PPARβ | NR1C2 | Fatty acids |
PPARγ | NR1C3 | Fatty acids, prostaglandin J2, thiazolidinediones |
Rev-erbα | NR1D1 | Orphan |
Rev-erbβ | NR1D2 | Orphan |
RORα | NR1F1 | Cholesterol, cholesteryl sulfate |
RORβ | NR1F2 | Retinoic acid |
RORγ | NR1F3 | Orphan |
LXRα | NR1H3 | Oxysterols, T0901317, GW3965 |
LXRβ | NR1H2 | Oxysterols, T0901317, GW3965 |
FXRα | NR1H4 | Bile acids, fexaramine |
FXRβa | NR1H5 | Lanosterol |
VDR | NR1I1 | Vitamin D, 1,25-dihydroxyvitamin D3 |
PXR | NR1I2 | Xenobiotics, 16α-cyanopregnenolone |
CAR | NR1I3 | Xenobiotics, phenobarbital |
HNF4α | NR2A1 | Orphan |
HNF4γ | NR2A2 | Orphan |
RXRα | NR2B1 | Retinoic acid |
RXRβ | NR2B2 | Retinoic acid |
RXRγ | NR2B3 | Retinoic acid |
TR2 | NR2C1 | Orphan |
TR4 | NR2C2 | Orphan |
TLL | NR2E2 | Orphan |
PNR | NR2E3 | Orphan |
COUP-TFI | NR2F1 | Orphan |
COUP-TFII | NR2F2 | Orphan |
EAR2 | NR2F6 | Orphan |
ERα | NR3A1 | Estradiol-17β, tamoxifen, raloxifene |
ERβ | NR3A2 | Estradiol-17β, various synthetic compounds |
ERR α | NR3B1 | Orphan |
ERRβ | NR3B2 | DES, 4-OH tamoxifen |
ERRγ | NR3B3 | DES, 4-OH tamoxifen |
GR | NR3C1 | Cortisol, dexamethasone, RU486 |
MR | NR3C2 | Aldosterone, spirolactone |
PR | NR3C3 | Progesterone, medroxyprogesterone acetate, RU486 |
AR | NR3C4 | Testosterone, flutamide |
NGFI-B | NR4A1 | Orphan |
NURR1 | NR4A2 | Orphan |
NOR1 | NR4A3 | Orphan |
SF1 | NR5A1 | Orphan |
LRH-1 | NR5A2 | Orphan |
GCNF | NR6A1 | Orphan |
DAX-1 | NR0B1 | Orphan |
SHP | NR0B2 | Orphan |
↵ a FXRβ is a pseudogene in human but is a functional lanosterol receptor in mouse (Robinson-Rechavi et al., 2001; Otte et al., 2003)