Endogenous ligands and primary biologic activities of NR1 subgroup receptors NR1H1 is the insect ecdysone receptor.
| Receptor | Major Sites of Expression | Endogenous Ligand/Activator | Primary Function |
|---|---|---|---|
| LXRα (NR1H3) | Liver, intestine, fat, lung, macrophage | Oxysterols | Cholesterol homeostasis |
| LXRβ (NR1H2) | Broadly expressed | Oxysterols | Cholesterol homeostasis |
| FXR (NR1H4) | Liver, intestine, kidney | Bile acids | Bile acid homeostasis |
| VDR (NR1I1) | Intestine, thyroid, kidney | 1,25(OH)2D3 | Calcium homeostasis |
| CAR (NR1I2) | Liver, intestine, choroid plexus | Bile acids,a bilirubina | Detoxification |
| PXR (NR1I3) | Liver, intestine | Bile acids | Detoxification |
↵ a Elevated levels of bile acids and bilirubin activate CAR indirectly via induction of nuclear translocation, not by functioning directly as agonists