FXRβ
| Receptor Nomenclature | NR1H5 |
| Receptor code | 4.10.1:BA:1:H5 |
| Other names | |
| Molecular information | Hs: |
| Mm: 505aa, Q80ST6, chr. 3 F2.21 | |
| DNA binding | |
| Structure | Heterodimer |
| HRE core sequence | AGTTCA N TGAACT (ER2) |
| Partners | |
| Agonists | Lanosterol (1 μM), vitamin D3 (10 μM), cholesten (10 μM), desmosterol (10 μM) [EC50]1 |
| Antagonists | |
| Coactivator | NCOA11 |
| Corepressor | |
| Biologically important isoforms | FXRβ -isoform 1 {Mm}1; FXRβ -isoform 2 {Mm}: splice variant in exon 81; FXRβ -isoform 3 {Mm}: splice variant in exon 10, lacking exon 111; FXRβ -isoform 4 {Mm}: splice variants in exon 8 and 10, lacking exon 111; FXRβ -isoform 5 {Mm}: splice variant in exon 31 |
| Tissue distribution | Ubiquitous {Mm} [RT-PCR]1 |
| Functional assay | |
| Main target genes | |
| Mutant phenotype | |
| Human disease |
aa, amino acids; chr., chromosome; HRE, hormone response element; RT-PCR, reverse transcriptase-polymerase chain reaction
↵1. tte K, Kranz H, Kober I, Thompson P, Hoefer M, Haubold B, Remmel B, Voss H, Kaiser C, Albers M, et al. (2003) Identification of farnesoid X receptor β as a novel mammalian nuclear receptor sensing lanosterol. Mol Cell Biol 23: 864-872