Receptor Nomenclature NR2B2
Receptor code 4.10.1:RX:2:B2
Other names H-2RIIBP, RCoR-1,
Molecular information Hs: 533aa, P28702, chr. 6p21.31,2
Rn: 458aa, P497433
Mm: 520aa, P28704, chr. 172,47
DNA binding
   Structure Homodimer, heterodimer, RXR partner
   HRE core sequence AGGTCA (DR-1, DR-2, DR-3, DR-4, DR-5)
Partners TR2 and TR4 (physical, functional): DNA binding2,810; VDR (physical, functional): DNA binding810; RARα, RARβ, and RARγ (physical, functional): DNA binding2,814; PPARα, PPARβ, and PPARγ (physical, functional): DNA binding10,15,16; LXRα and LXRβ (physical, functional): DNA binding10,1721; FXR (physical, functional): DNA binding10,22; PXR (physical, functional): DNA binding10,2326; CAR (physical, functional): DNA binding10,27,28; NGFI-B (physical, functional): DNA binding10,29,30; NURR1 (physical, functional): DNA binding10,30
Agonists LG100268 (3–6.8 nM), LGD1069 (21 nM),* 9-cis-retinoic acid (6.2–117 nM),* [IC50]7,3139; AGN194204 (3.6 nM) [Kd]40
Antagonists LG100754 (10 nM) [IC50]36,41,42
Coactivators NCOA1, NCOA2, NCOA310,4347
Biologically important isoforms RXRβ 1 {Hs, Mm}: differs from RXRβ 2 in the A/B domain48,49; RXRβ 2 {Hs, Mm}49,50
Tissue distribution Ubiquitous {Hs, Mm, Rn} [Northern blot, in situ hybridization, Western blot]3,4,7,51
Functional assays Differentiation of 3T3-L1 cells to adipocytes measured by the accumulation of triglyceride produced within the cytoplasm of the adipocyte {Mm}34,52,53; induction of apoptosis (associated with RARα activation) in leukemia cell lines {Hs}38,54
Mutant phenotype Male sterility due to defective spermatogenesis, abnormal lipid metabolism in Sertoli cells and behavioral defects {Mm} [knockout]18,5557
  • aa, amino acid; chr, chromosome; HRE, hormone response element; NGFI-B, nerve growth factor-induced clone B

  • * Radioligand

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