Receptor Nomenclature NR2B1
Receptor code 4.10.1:RX:2:B3
Molecular information Hs: 463aa, P48443, chr. 1q22-q231,2
Mm: 463aa, P28705, chr. 125
DNA binding
   Structure Homodimer, heterodimer, RXR partner
   HRE core sequence AGGTCA (DR-1, DR-2, DR-3, DR-4, DR-5)
Partners TR2 and TR4 (physical, functional): DNA binding58; VDR (physical, functional): DNA binding68; RARα, RARβ, and RARγ (physical, functional): DNA binding512; PPARα, PPARβ, and PPARγ (physical, functional): DNA binding8,13,1 4; LXRα and LXRβ (physical, functional): DNA binding8,1518; FXR (physical, functional): DNA binding8,19; PXR (physical, functional): DNA binding8,2023; CAR (physical, functional): DNA binding8,24,2 5; NGFI-B (physical, functional): DNA binding8,26,2 7; NURR1 (physical, functional): DNA binding8,27
Agonists LG100268 (3–9.7 nM), LGD1069 (29 nM),* 9-cis-retinoic acid (9.7–85 nM)* [IC50]2836; AGN194204 (3.8 nM) [Kd]37
Antagonists LG100754 (12.2 nM) [IC50]33,38,39
Coactivators NCOA1, NCOA2, NCOA38,4044
Biologically important isoforms RXRγ1 {Mm}: differs from RXRγ 2 in the A/B domain45,46; RXRγ2 {Mm}45,46.
Tissue distribution RXRγ1 is expressed in the brain and muscle, whereas RXRγ 2 is highly expressed in both cardiac and skeletal muscles {Mm, Rn} [Northern blot, in situ hybridization, Western blot]45,4749
Mutant phenotype Knockout mice have metabolic and behavioral defects {Mm} [knockout]5054
  • aa, amino acid; chr, chromosome; HRE, hormone response element; NGFI-B, nerve growth factor-induced clone B

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