TABLE 1

TLR targets in different diseases

TLR Tissue Therapeutic Potential/Use Action
TLR2 Heart/vasculature Atherosclerosis Antagonistic
Lung Asthma Antagonistic
Kidney Ischemia/reperfusion Antagonistic
Pancreas Diabetes Antagonistic
TLR3 Systemic Vaccine adjuvant Agonistic
Breast Anti-cancer Agonistic
Renal system Anti-cancer Agonistic
Eye CNV inhibition in AMD Agonistic
Brain Anti-viral (WNV) Antagonistic
TLR4 Heart/vasculature Atherosclerosis Antagonistic
Lung Asthma Antagonistic
Kidney Ischemia/reperfusion Antagonistic
Pancreas Diabetes Antagonistic
Joints Rheumatoid arthritis Antagonistic
Brain Alzheimer's disease, Parkinson's disease Antagonistic
Systemic Sepsis Antagonistic
Vaccine adjuvant Agonistic
TLR5 Hematopoietic system and GI tract Radio-protective Agonistic
Systemic Vaccine-adjuvant (influenza virus) Agonistic
GI tract Treatment of Crohn's disease Antagonistic
TLR7/8 Skin Treatment of viral induced lesions (caused by papilloma virus and Herpes simplex virus) Agonistic
Primary tumors Agonistic
Cutaneous metastases Agonistic
Anti-viral (HCV) Agonistic
Blood Chronic lymphocyte leukemia Agonistic
Systemic SLE Antagonistic
TLR9 Prostate Anticancer Agonistic
Systemic Vaccine-adjuvant Agonistic
Systemic Tumor-vaccine-adjuvant Agonistic
Lung/systemic Asthma/allergy Agonistic