Name | In Vitro: EC50 in Different Species | In Vivo: Effect on Deep Tb | ||||
---|---|---|---|---|---|---|
Rat | Mouse | Human | Species | Dose and Route | Effect | |
nM | nM | nM | mg/kg | |||
AEA | 350–1560a–c | 3000d | 520–550c,e,f | Rat | 10–20 i.p. | ↓g |
Mouse | 10–40 i.v. | ↓h,i | ||||
NADA | 48c | — | 26–63c,e,j | Mouse | 10 i.p. | ↓k |
OEA | 2000l | — | — | Rat | 20 i.v. | ↓m |
Mouse | 10 i.v. | ↓i | ||||
OLDA | 1800n | 258o | 36j | — | — | — |
CAP | 10–42a–c,n | 9–300d,o> | 19–34c,e,f,j> | Rat | Varied | ↓p |
Mouse | 1–15 s.c. | ↓q | ||||
RTX | 0.17a | 0.15o | — | Rat | Varied | ↓p |
Mouse | 0.0005–0.02 i.p., s.c. | ↓r |
↓, decrease in deep Tb; —, not studied.
↵a Ross et al. (2001).
↵b Di Marzo et al. (2001).
↵c Huang et al. (2002).
↵d Roberts et al. (2002).
↵e De Petrocellis et al. (2000).
↵f De Petrocellis et al. (2001).
↵g Crawley et al. (1993).
↵h Adams et al. (1998); Wiley et al. (2006).
↵i Watanabe et al. (1999).
↵j Chu et al. (2003).
↵k Bisogno et al. (2000).
↵l Ahern (2003).
↵m Proulx et al. (2005). The effect on deep Tb, although not measured in this study, is an assumption based on the measured effect on heat expenditure.
↵n Szolcsányi et al. (2004).
↵o Correll et al. (2004).
↵p For review and references, see section IV.B.1.
↵q de Vries and Blumberg (1989); Caterina et al. (2000).
↵r de Vries and Blumberg (1989); Steiner et al. (2007).