Subcellular localization of uptake Oct, Octn, Oat, and Urat transporters in various species
For each transporter, the apical or basolateral localization in a particular tissue and/or species is provided. Species included rat (R), mouse (M), human (H), and bovine (B). Detailed information regarding particular cellular populations or regions of the tissue are provided for some transporter isoforms.
Cellular Localization | Tissue | Species | Cell Types | References |
---|---|---|---|---|
Oct1 | ||||
Basolateral | Liver | R | Hepatocytes (centrilobular) | Meyer-Wentrup et al., 1998 |
Basolateral | Kidney | R | Proximal tubule cells (S1/S2) | Karbach et al., 2000 |
Basolateral | Jejunum | H | Enterocytes | Muller et al., 2005 |
Basolateral | Testes | R | Sertoli cells | Maeda et al., 2007a |
Apical | Lung | R, H | Ciliated epithelial cells | Lips et al., 2005 |
Oct2 | ||||
Basolateral | Kidney | R, H | Proximal tubule cells (S2/S3) | Karbach et al., 2000; Motohashi et al., 2002 |
Apical | Lung | R, H | Ciliated epithelial cells | Lips et al., 2005 |
Apical | Choroid plexus | R | Epithelial cells | Sweet et al., 2001 |
Apical | Olfactory mucosa | B | Epithelial cells | Chemuturi and Donovan, 2007 |
Oct3 | ||||
Basolateral | Kidney | H | Proximal tubule cell line | Glube and Langguth, 2008 |
Basolateral | Placenta | H | Syncytiotrophoblasts | Sata et al., 2005 |
Apical | Jejunum | H | Enterocytes | Muller et al., 2005 |
Apical | Testes | R | Sertoli cells | Maeda et al., 2007a |
Apical | Lung | R, H | Ciliated epithelial cells | Lips et al., 2005 |
Octn1 | ||||
Apical | Kidney | M | Proximal tubule cells | Tamai et al., 2004 |
Apical | Eye | H | Corneal-limbal and conjunctival epithelium | Garrett et al., 2008 |
N.D. | Heart | M | Endothelial cells in blood vessels | Iwata et al., 2008 |
Octn2 | ||||
Apical | Kidney | M, R, H | Proximal tubule cells | Tamai et al., 2001a; Masuda et al., 2006 |
Apical | Placenta | H | Syncytiotrophoblasts | Lahjouji et al., 2004; Grube et al., 2005 |
Apical | Small intestine | R | Enterocytes | Duran et al., 2005 |
Apical | Eye | H | Corneal-limbal and conjunctival epithelium | Garrett et al., 2008 |
Apical | Epididymis | M | Principal cells, spermatozoa | Yakushiji et al., 2006; Kobayashi et al., 2007 |
Basolateral | Epididymis | R | Epithelia of distal caput and corpus | Rodriguez et al., 2002 |
Basolateral | Testes | R | Sertoli cells | Kobayashi et al., 2005a |
Basolateral | Brain | R | Capillary endothelial cells | Miecz et al., 2008 |
N.D. | Brain | M, R | Olfactory bulb and nerve, cortex, cerebellum, spinal cord, hippocampus, hypothalamus, choroid plexus, astrocytes | Inazu et al., 2006; Lamhonwah et al., 2008 |
N.D. | Pancreas | M | α Cells | Kai et al., 2005 |
N.D. | Heart | M, H | Cardiac muscle cells, endothelial cells | Grube et al., 2006b; Iwata et al., 2008 |
Octn3 | ||||
Basolateral | Small intestine | R | Enterocytes | Duran et al., 2005 |
N.D. | Epididymis | M | Spermatozoa | Kobayashi et al., 2007 |
N.D. | Brain | M | Olfactory bulb and nerve, cortex, cerebellum, grey matter, hippocampus, hypothalamus, choroid plexus | Lamhonwah et al., 2008 |
Oat1 | ||||
Basolateral | Kidney | M, R, H | Proximal tubule cells | Hosoyamada et al., 1999; Tojo et al., 1999; Eraly et al., 2006 |
Basolateral | Choroid plexus | M | Ependymal cells | Bahn et al., 2005 |
N.D. | Muscle | H | Skeletal muscle cells | Takeda et al., 2004 |
N.D. | Adrenal gland | R | Outer zona fasciculate | Beery et al., 2003 |
Oat2 | ||||
Basolateral | Liver | R | Hepatocytes | Simonson et al., 1994 |
Basolateral | Kidney | H | Proximal tubule cells | Enomoto et al., 2002b |
Apical | Kidney | M, R | Proximal tubule cells | Kojima et al., 2002; Ljubojevic et al., 2007 |
Oat3 | ||||
Basolateral | Kidney | M, R, H | Proximal tubule cells | Cha et al., 2001; Kojima et al., 2002; Bahn et al., 2005 |
Basolateral | Eye | R | Retinal vascular endothelial cells | Hosoya et al., 2008 |
Basolateral | Brain | R | Capillary endothelial cells | Kikuchi et al., 2003; Roberts et al., 2008 |
Apical | Choroid plexus | M | Epithelial cells | Sweet et al., 2002; Sykes et al., 2004 |
N.D. | Muscle | H | Skeletal muscle cells | Takeda et al., 2004 |
Oat4 | ||||
Apical | Kidney | H | Proximal tubule cells | Babu et al., 2002a; Ekaratanawong et al., 2004 |
Basolateral | Placenta | H | Syncytiotrophoblasts | Ugele et al., 2008 |
Oat5 | ||||
Apical | Kidney | R | Proximal tubule cells | Anzai et al., 2005 |
Oat6 | ||||
N.D. | Olfactory mucosa | M | Olfactory cells | Monte et al., 2004 |
Oat7 | ||||
Basolateral | Liver | H | Hepatocytes | Shin et al., 2007 |
Urat1 | ||||
Apical | Kidney | M, H | Proximal tubule cells | Enomoto et al., 2002a; Hosoyamada et al., 2004 |
N.D., not determined.