TABLE 7

Apparent cannabinoid CB1 receptor-independent effects of cannabinoid receptor agonists on ion channels other than TRP channels

See Section III.F for references and further discussion.

Ion Channel and EffectEndocannabinoid(s)?Effective Concentration RangeNonendogenous Cannabinoid Agonist(s)?Effective Concentration Range
Current enhancement/activation
    KCa (BK) K+YesaNanomolar or micromolarYesbNanomolar or micromolar
    Voltage-gated Na+NoMicromolarYesNanomolar
Inhibition
    Ca2+ (native)YescNanomolar or micromolarYesbMicromolar
    T-type Ca2+ (CaV3.1)YescMicromolarYesMicromolar
    T-type Ca2+ (CaV3.2)Yesa,cNanomolar or micromolarYesMicromolar
    T-type Ca2+ (CaV3.3)YescMicromolarYesMicromolar
    T-type Ca2+ (native)N.D.N.D.YesMicromolar
    N-, P-, or P/Q-type Ca2+YescMicromolarYesMicromolar
    KATP K+Yesc,dMicromolarYesbMicromolar
    TASK-1 K+Yesa,cNanomolar or micromolarYesNanomolarb or micromolar
    TASK-3 K+YescMicromolarYesbMicromolar
    Voltage-gated K+ (KV)YescNanomolar or micromolarYesNanomolarb or micromolar
    Voltage-gated Na+YesMicromolarYesMicromolare
Radioligand binding (↓)
    L-type Ca2+Yesc,dMicromolarYesbMicromolar
    KATP K+Yesc,dMicromolarYesbMicromolar
    Voltage-gated Na+YesdMicromolarYesdMicromolar

  • N.D., no data.

  • ↵a Anandamide but not 2-arachidonoyl glycerol.

  • ↵b Only R-(+)-methanandamide.

  • ↵c Also R-(+)-methanandamide.

  • ↵d May target an allosteric site on this ion channel.

  • ↵e Slight enhancement of sodium currents has also been detected in response to 10 nM R-(+)-WIN55212 (section III.G.3.).