Substrate | Km | Expression System | Reference |
---|---|---|---|
μM | |||
Bile acids | |||
Cholic acid | 11 | HEK293 | Cui et al., 2001 |
Glycocholic acid | + | XO | Kullak-Ublick et al., 2001 |
Glycoursodeoxycholic acid | + | HEK293 | Maeda et al., 2006b |
Taurolithocholic acid 3-sulfate | + | MDCKII | Sasaki et al., 2002 |
Taurocholic acid | 34 | HEK293c18 | Hsiang et al., 1999 |
14 | XO | Abe et al., 1999 | |
+ | HEK293 | König et al., 2000b | |
10 | HEK293 | Cui et al., 2001 | |
Tauroursodeoxycholic acid | + | HEK293 | Maeda et al., 2006b |
Thyroid hormones | |||
Thyroxine | + | HEK293c18 | Hsiang et al., 1999 |
3.0 | XO | Abe et al., 1999 | |
Triiodothyronine | 2.7 | XO | Abe et al., 1999 |
Iodothyronine sulfates | + | COS1 | van der Deure et al., 2008 |
Eicosanoids | |||
Leukotriene C4 | + | XO | Abe et al., 1999 |
Leukotriene E4 | + | XO | Abe et al., 1999 |
Prostaglandin E2 | + | XO | Abe et al., 1999 |
+ | HEK293 | Tamai et al., 2000 | |
Thromboxane B2 | + | XO | Abe et al., 1999 |
Others | |||
Bilirubin | 0.16 | HEK293 | Cui et al., 2001 |
0.0076 | XO | Briz et al., 2003 | |
Bilirubin monoglucuronide | 0.1 | HEK293 | Cui et al., 2001 |
Bilirubin diglucuronide | 0.3 | HEK293 | Cui et al., 2001 |
CCK-8 | + | HEK293 | Hirano et al., 2004 |
DHEAS | + | XO | Abe et al., 1999 |
22 | HEK293 | Cui et al., 2001 | |
E217βG | + | XO | Abe et al., 1999 |
8.2 | HEK293 | König et al., 2000b | |
9.7 | XO | Nakai et al., 2001 | |
3.7 | XO | Tamai et al., 2001 | |
8.2 | HEK293 | Cui et al., 2001 | |
28 | MDCKII | Sasaki et al., 2002 | |
8.3 | HEK293 | Hirano et al., 2004 | |
6.3 | HEK293 | Sharma et al., 2009 | |
E1S | + | XO | Abe et al., 1999 |
0.2 | HEK293 | Tamai et al., 2000 | |
5.3 | XO | Tamai et al., 2001 | |
13 | HEK293 | Cui et al., 2001 | |
0.5 | HEK293 | Hirano et al., 2004 | |
+ | MDCKII | Kopplow et al., 2005 | |
0.23, 45 | HEK293 | Noé et al., 2007 | |
+ | COS1 | van der Deure et al., 2008 | |
+ | Flp-In-293 | Nakakariya et al., 2008 |
CCK-8, cholecystokinin octapeptide; CHO, Chinese hamster ovary; DADLE, [d-Ala2,d-Leu5]-enkephalin (opioid peptide analog); DHEAS, dehydroepiandrosterone sulfate; E217βG, estradiol-17β-D-glucuronide; E1S, estrone-3-sulfate; HEK293, human embryonic kidney 293 cells; HepG2, a human liver carcinoma cell line; MDCKII, Madin-Darby canine kidney cells; XO, Xenopus laevis oocyte; +, substrate of OATP1B1, but Km not available.