Dopamine Receptor Subtype | D1 | D2 | D3 | D4 | D5 |
---|---|---|---|---|---|
Gene symbol | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 |
Chromosomal gene map locus | 5q35.1 | 11q23.1 | 3q13.3 | 11p15.5 | 4p16.1 |
Number of introns in the coding region | None | 6 | 5 | 3 | None |
Pseudogenes | None | None | None | None | DRD5P1, DRD5P2 |
Presence of splice variants | None | Yes D2S, D2L | Yes | Yes | None |
Number of amino acids | 446 | D2S, 414; D2L, 443 | 400 | 387 | 477 |
Molecular weight | 49,300 | D2S, 47,347; D2L, 50,619 | 44,225 | 41,487 | 52,951 |
G protein coupling | Gαs, Gαolf | Gαi, Gαo | Gαi, Gαo | Gαi, Gαo | Gαs, Gαq |
Selective agonists | Fenoldopam, SKF-38393, SKF-81297 | Bromocriptine, pergolide, cabergoline, ropinirole | 7-OH-DPAT, pramipexole, rotigotine, (+)-PD-128907 | A-412997, ABT-670, PD-168,077 | None |
Selective antagonists | SCH-23390, SCH-39166, SKF-83566 | Haloperidol, spiperone, raclopride, sulpiride, risperidone | Nafadotride, GR 103,691, GR 218,231, SB-277011A | A-381393, FAUC 213, L-745,870, L-750,667 | None |
7-OH-DPAT, hydroxy-2-dipropylaminotetralin; A-381393, 2-[4-(3,4-dimethylphenyl)piperazin-1-ylmethyl[-1H benzimidazole; A-412997, N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide; ABT-670, 3-methyl-N-(1-oxy-3′,4′,5′,6′-tetrahydro-2′H-[2,4′-bipyridine]-1′-ylmethyl)benzamide; FAUC 213, 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine; GR 218,231, (+)-(2R)-1,2,3,4-tetrahydro-6-[[(4-methoxyphenyl)sulfonyl[methyl]-N,N-dipropyl-2-naphthalenamine; GR 103,691, 4′-acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1′-biphenyl]-4-carboxamide; L-745,870, 3-(4-[4-chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine; L-750,667, 3-[4-(4-iodophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine; PD-128907, (4aR,10bR)-3,4a,4,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol; PD-168,077, N-{[4-(2-cyanophenyl)piperazin-1-yl]methyl}-3-methylbenzamide-(2Z)-but-2-enedioic acid; ; SB-277011A, N-{trans-4-[2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]cyclohexyl}quinoline-4-carboxamide; SCH-39166, (−)-trans-6,7,7α,8,9,13β-hexahydro-3-chloro-2-hydroxy-N-methyl-5H-benzo[d]naphtho[2,1-b]azepine; SKF-38393, 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; SKF-81297, (±)-6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide; SKF-83566, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol.