TABLE 1

Some genetically modified animals useful to delineate adenosine receptor functions

Gene Targeted	Comment	References
AdoRA1	Major portion of coding exon 2 + ∼5 kb adjacent 3′ genomic seq; not lethal.	Johansson et al., 2001
	3′ portion of coding exon 1 + intron 5′ portion of coding exon 2, not lethal	Sun et al., 2001
AdoRA2A	Entire coding exon 2, not lethal	Ledent et al., 1997
	3′ portion of coding exon 2 ∼1.0 kb immediate intron seq, not lethal	Chen et al., 1999, 2001a
AdoRA2B	Replacement of exon 1 of the A_2BAR with a reporter construct containing the β-gal gene; not lethal.	Yang et al., 2006
	Replacement of part of the intron and the entirety of exon 2 (amino acids 113–332) with a marker gene; not lethal.	Hua et al., 2007b
AdoRA3	Entire coding exon 1 + 7.5 kb immediate intron seq; not lethal	Salvatore et al., 2000
Adenosine kinase	In frame insertion at exon amino acid Gly169-Thr225; die at P4	Boison et al., 2002
Adenosine deaminase	In frame insertion at exon 5; perinatal death Die at 3 weeks after trophoblast rescue	Blackburn et al., 1998
CD39	Part of exon 1; not lethal.	Enjyoji et al., 1999
CD73	Entire exon 3 + intronic sequences; not lethal.	Thompson et al., 2004
	Entire exon 2; not lethal.	Koszalka et al., 2004