TABLE 1

Summary of drug-induced changes associated with behavioral sensitization and reinstatement

See text for relevant citations.

Brain RegionSensitizationReinstatement
VTA
    Dopamine releaseIncreasedUnknown
    Autoreceptor functionDecreasedUnknown
    Glutamate releaseIncreasedUnknown
    AMPA functionIncreasedIncreased
    LTPTransientProlonged
Nucleus accumbens
    Dopamine releaseIncreasedIncreased or decreased
    Basal glutamateDecreasedDecreased
    Glutamate releaseIncreasedIncreased
    AMPA functionIncreasedIncreased
    mGluR2/3 functionDecreasedDecreased
mPFC
    Dopamine releaseIncreased (Delayed)Unknown
    D2 functionDecreasedUnknown
    Glutamate releaseIncreased (Transient)Unknown
    Group II mGluR functionDecreasedUnknown