GPCR | PDZ-Binding Motif | NHERF Target | Function | Reference |
---|---|---|---|---|
PTHR | E-T-V-M | PDZ1 NHERF1 | Gαs, Gαq, Gαi, PLCβ, PKA, PKC, MAP kinase signaling | Mahon et al., 2002; Sneddon et al., 2003; Mahon and Segre, 2004; Wang et al., 2007 |
PDZ2 NHERF2 | Receptor trafficking & desensitization | Wheeler et al., 2008 | ||
Npt2a regulation | Wang et al., 2008, 2009, 2010; Weinman et al., 2009, 2011 | |||
β2-AR | D-S-L-L | PDZ1 NHERF1 | NHE3 & CFTR regulation | Hall et al., 1998; Naren et al., 2003; Taouil et al., 2003; Singh et al., 2009 |
PDZ1,2 NHERF2 | ||||
PDZ2 NHERF3 | ||||
κOR | N-K-P-V | PDZ1 NHERF1 | Receptor recycling | Li et al., 2002 |
NHE3 regulation | Huang et al., 2004; Liu-Chen, 2004 | |||
mGluR5 | S-S-S-L | PDZ2 NHERF2 | Prolong calcium mobilization | Paquet et al., 2006 |
Potentiate cell death | ||||
P2Y1 | D-T-S-L | PDZ1 NHERF1 | PLCβ signaling | Hall et al., 1998 |
AKAP activity (via ezrin) | Fam et al., 2005 | |||
PDZ1, PDZ2 NHERF2 | CFTR regulation | Guerra et al., 2004 | ||
Receptor dimerization | Choi et al., 2008 | |||
LPA2 (LPA5) | D-S-T-L | PDZ2 NHERF2 | Gαq, Gαi, PLCβ, Akt, MAP kinase signaling | Oh et al., 2004 |
Choi et al., 2010 | ||||
CFTR regulation (LPA5: NHE3) | Li et al., 2005; Singh et al., 2009 | |||
Antiapoptotic signaling | Yun et al., 2005; E et al., 2009; Lee et al., 2011 | |||
Cell migration | Cha et al., 2010; Lin et al., 2010 | |||
CCR5 | S-V-G-L | PDZ2 NHERF1 | Receptor internalization & dimerization | Hammad et al., 2010 |
MAP kinase signaling | ||||
CLRL | D-T-L-L | PDZ1 NHERF1 | Receptor internalization | Bomberger et al., 2005a,b |
RAMP3 | ||||
A2b | ? | NHERF2 | Membrane anchoring | Sitaraman et al., 2002 |
TXA2 | Indirect | PDZ 1&2 NHERF1 | Gαq & PLCβ signaling | Rochdi et al., 2002; Rochdi and Parent, 2003 |
Fzd (Fzd4) | X-S/T-X-V/L (ETVV) | PDZ2 NHERF2 | Wnt/β-catenin signaling Tumor suppressor in breast cancer | Wheeler et al., 2011 |
MAP, mitogen-activated protein; AKAP, A kinase anchoring protein; Akt, protein kinase B.