TABLE 2

Summary of hot plate antinociception and antinociceptive tolerance responses in mice deficient in individual GRKs in response to short-term morphine and fentanyl treatment

	GRK2-HT	GRK3-KO	GRK4-KO	GRK5-KO	GRK6-KO
Hot plate antinociception
Morphine	=^{^a}	=^{^b}	=^{^a}	=^{^a}	=^{^a,^c}
Fentanyl	N.D.	=^{^b}	N.D.	N.D.	N.D.
Hot plate antinociceptive tolerance
Morphine	=^{^d}	=^{^b}	=^{^d}	=^{^d}	=^{^c}
Fentanyl	N.D.	↓^{^b}	N.D.	N.D.	N.D.

=, equivalent to wild type (WT) response at 10 mg/kg s.c.; ↓, significant decrease in response; N.D., not determined; HT, heterozygote.
↵a Bohn et al., 2004.
↵b Terman et al., 2004.
↵c Raehal and Bohn, 2011.
↵d K. Raehal and L. Bohn, unpublished observations.