TABLE 3

Sex differences in transporter expression in mouse and rat tissues

Reported sex differences in mRNA expression in selected OAT family members and the effect of hormonal regulation is summarized. Hormonal regulation was investigated through gonadectomy (GNX), hypophysectomy (HPX) and gonadectomy followed by hormone-replacement therapy (estrogen/dihydrotestosterone, DHT) in male and female animals.

TransporterTissueSex PredominantFemaleMaleReferences
GNXHPXEstrogenGNXHPXDHT
rOat1KidneyM > FBuist et al., 2003; Ljubojevic et al., 2004; Cheng et al., 2007
mOat1KidneyM > FBuist and Klaassen, 2004
rOat2KidneyF > MBuist et al., 2003; Ljubojević et al., 2007
rOat3LiverM > FBuist et al., 2003; Ljubojevic et al., 2004; Cheng et al., 2007
rOat5KidneyF > MBreljak et al., 2010
mOat5KidneyF > MBreljak et al., 2010
mUrat1KidneyM > FHosoyamada et al., 2004
  • M, male; F, female; ↑, increase; ↓, decrease; ↔, no change; —, measurements were not carried out.