TABLE 2

Changes in gene expression in CP-r cells determined by reverse transcription-polymerase chain reaction, immunoblotting, immunofluorescence, and functional cloning

Type of proteinExpressionGeneReference
Membrane proteinsReducedMRP1, MRP2Liang et al., 2003; Shen et al., 2000
MRP4, MRP5D.-W. Shen and M. M. Gottesman, unpublished data
FBPLiang et al., 2003; Shen et al., 2004a
Small GTPasesReducedRab5, Rac1, RhoAShen et al., 2004b
Transcription/regulationReducedHistone H1, Histone H3D.-W. Shen and M. M. Gottesman, unpublished data
CytoskeletonReducedβ-actin, F-actin, α-tubulin, β-tubulin, Dyn2, filamin 90 and 250, keratin 5/8Liang et al., 2008; Shen et al., 2000); D.-W. Shen and M. M. Gottesman, unpublished data
Endocytic/exocyticReducedERC, STX6D.-W. Shen and M. M. Gottesman, unpublished data
Tumor suppressorReducedMaspinA. Pai-Panandiker and M. M. Gottesman, unpublished data
Membrane proteinsIncreasedCaveolin, Ror1 (transmembrane TMEM205 receptor)Shen et al., 2010; D.-W. Shen and M. M. Gottesman, unpublished data
Small GTPasesIncreasedRab8Shen and Gottesman, 2011
Transcription/RegulationIncreasedSIRT1Liang et al., 2008
GCF2Shen et al., 2012
ChaperonesIncreasedHSP60Shen et al., 1995
HSP10Shen et al., 2006
Ribosomal proteinsIncreasedRPL36, RPL36a, RPL27Shen et al., 2006
EnzymesIncreasedALDH3 [Aldehyde dehydrogenase III], ACADM (acyl-CoA dehydrogenase, C4 to C12, straight chainD.-W. Shen and M. M. Gottesman, unpublished data