TABLE 1

Gene loci and tissue distribution of hOATs

Gene Name	Gene Locus	Protein			Tissue Distribution		Cell Types	Membrane Localization	Reference
Gene Name	Gene Locus	Isoform	Amino Acid Length	Predicted Molecular Mass	mRNA	Protein	Cell Types	Membrane Localization	Reference
				kDa
SLC22A6	11q12.3	hOAT1	563	61	Kidney	Kidney	Proximal tubule cells	Basolateral	Hosoyamada et al., 1999; Alebouyeh et al., 2003; Eraly et al., 2003a; Ahn and Nigam, 2009
					Skeletal muscle		Skeletal muscle cells	N.D.
						Choroid plexus	Epithelial cells	N.D.
					Brain		N.D.	N.D.
					Placenta		Syncytiotrophoblasts	N.D.
SLC22A7	6p21.2-21.1	hOAT2	548	60	Liver		Hepatocytes	N.D.	Sun et al., 2001; Enomoto et al., 2002b; Shin et al., 2010
					Kidney	Kidney	Proximal tubule cells	Basolateral	Sun et al., 2001; Enomoto et al., 2002b; Shin et al., 2010
SLC22A8	11q12.3	hOAT3	542	60	Kidney	Kidney	Proximal tubule cells	Basolateral	Cha et al., 2001; Motohashi et al., 2002; Alebouyeh et al., 2003; Bakhiya et al., 2003; Dantzler and Wright, 2003; Asif et al., 2005
					Adrenal gland		N.D.	N.D.
					Skeletal muscle		Skeletal muscle cells	N.D.
					Choroid plexus	Choroid plexus	Epithelial cells	Apical/basolateral
SLC22A11	11q13.1	hOAT4	550	60	Kidney	Kidney	Proximal tubule cells	Apical	Cha et al., 2000; Babu et al., 2002b; Motohashi et al., 2002; Asif et al., 2005
					Adrenal gland		N.D.	N.D.
					Placenta	Placenta	Syncytiotrophoblasts	Basolateral
SLC22A10	11q12.3	hOAT5	541	60	Liver		N.D.	N.D.	Sun et al., 2001; Klein et al., 2010
SLC22A9	11q13.1	hOAT7	553	62	Liver	Liver	Hepatocytes	Basolateral	Shin et al., 2007
SLC22A12	11q13.1	hURAT1	553	60	Kidney	Kidney	Proximal tubule cells	Apical	Enomoto et al., 2002a; Komoda et al., 2004; Kikuchi et al., 2007
SLC22A13	3p21.3	hOAT10	551	61	Kidney	Kidney	N.D.	Luminal	Bahn et al., 2008
					Brain		N.D.	N.D.
					Heart		N.D.	N.D.
					Colon		N.D.	N.D.