Size comparisons for physical delivery in cancer and other applications
| Particle Sizes | Polymer | Delivery Method | Measured Response | Efficient size | Reference |
|---|---|---|---|---|---|
| 315 nm, 1 μm, 10 μm | PLGA | Intratumoral | Decrease in tumor volume | 1 and 10 μm | Chakravarthi et al., 2010 |
| Cubic particles with side length of 2, 3, or 5 μm | Cationic cross-linked PEG hydrogel | Incubated with HeLa cells for 4 h | Internalization | Cubic particles with side length of 2 μm | Gratton et al., 2008b |
| Cylindrical particles of D = 0.5 or 1 μm and H = 1 μm | Cationic cross-linked PEG hydrogel | Incubated with HeLa cells for 4 h | Internalization | No difference | Gratton et al., 2008b |
| Cylindrical particles of D = 150 nm and H = 450 nm (AR = 3) or D = 100 nm and H = 300 nm (AR = 3) | Cationic cross-linked PEG hydrogel | Incubated with HeLa cells for 4 h | Internalization extent and rate | Same extent; cylindrical particles of D = 150 nm and H = 450 nm internalize faster | Gratton et al., 2008b |
| 0.7, 1, 2.5, 3 μm | Silica beads | I.V. | Accumulation in heart, tumor, kidney and brain | Increased accumulation with decreased diameter; N.B., also affected by injected dose | Decuzzi et al., 2010 |
D, diameter; H, height; AR, aspect ratio.