Transporter regulation by HNF1α, HNF1β, and HNF4α transcription factors
Transcription factors used for mRNA expression in mouse models (in vivo) and human cell models (in vitro). In all cases, mRNA levels increased.
| Transporter and Model System | Transcription Factor | Reference |
|---|---|---|
| hOAT1 | ||
| HEK 293 cell line | HNF1α/β | Saji et al., 2008 |
| OK cell line | HNF4α | Ogasawara et al., 2007 |
| mOAT2 | ||
| Mouse kidney/liver | HNF1α | Maher et al., 2006 |
| hOAT2 | ||
| Huh7 cell line | HNF4α | Popowski et al., 2005 |
| hOAT3 | ||
| HEK 293 cell line | HNF1α/β | Kikuchi et al., 2006 |
| hURAT1 | ||
| HepG2 cell line | HNF1α/β | Kikuchi et al., 2007 |
| hOAT5 | ||
| Huh7/HepG2 cell line | HNF1α | Klein et al., 2010 |
| Huh7 cell line | HNF4α | Klein et al., 2010 |
| hOAT7 | ||
| Huh7/HepG2 cell line | HNF1α | Klein et al., 2010 |
| Huh7 cell line | HNF4α | Klein et al., 2010 |
OK, opossum kidney; Huh7 cells, hepatocellular carcinoma cells; HepG2, hepatocellular carcinoma cells.