TABLE 1

Nomenclature of orexin signaling components

The IUPHAR (International Union of Basic and Clinical Pharmacology) ID was retrieved from http://www.iuphar-db.org/DATABASE/FamilyMenuForward?familyId=51. The HGNC gene name is that approved by the Human Genome Nomenclature Committee. Chromosomal location is based on fluorescent in situ hybridization mapping (human) and ISCN (International System for Cytogenetic Nomenclature) lengths (mouse and rat) from UCSC Genome Bioinformatics (http://genome.ucsc.edu). ChEMBL is from the MedChem literature data on drug-like molecules and their targets.

IUPHAR IDaHGNC Gene NamebSpeciesHGNC SymbolGenomic LocusDatabases
IUPHAR Ligand IDEntrez IDUnigeneHGNCChEMBL
OX-A OX-BOrexin-A Orexin-BHumanHCRT17q21.11697 1699602358Hs0.1583484847N.A.
MouseHcrt11qD15171Mm0.10096
RatHcrt10q32.125723Rn0.7628
OX1 receptorHypocretin (orexin) receptor 1HumanHCRTR11p35.2N.A.3061Hs0.388226484810009
MouseHcrtr14qD2.223077Mm0.246595
RatHcrtrt5q3625593Rn0.88262
OX2 receptorHypocretin (orexin) receptor 2HumanHCRTR26p12.1N.A.3062Hs0.151624484912968
MouseHcrtr29qD387285Rn0.9893
RatHcrtr28q2425605Mm0.335300