Nomenclature of orexin signaling components
The IUPHAR (International Union of Basic and Clinical Pharmacology) ID was retrieved from http://www.iuphar-db.org/DATABASE/FamilyMenuForward?familyId=51. The HGNC gene name is that approved by the Human Genome Nomenclature Committee. Chromosomal location is based on fluorescent in situ hybridization mapping (human) and ISCN (International System for Cytogenetic Nomenclature) lengths (mouse and rat) from UCSC Genome Bioinformatics (http://genome.ucsc.edu). ChEMBL is from the MedChem literature data on drug-like molecules and their targets.
IUPHAR IDa | HGNC Gene Nameb | Species | HGNC Symbol | Genomic Locus | Databases | ||||
---|---|---|---|---|---|---|---|---|---|
IUPHAR Ligand ID | Entrez ID | Unigene | HGNC | ChEMBL | |||||
OX-A OX-B | Orexin-A Orexin-B | Human | HCRT | 17q21.1 | 1697 1699 | 602358 | Hs0.158348 | 4847 | N.A. |
Mouse | Hcrt | 11qD | 15171 | Mm0.10096 | |||||
Rat | Hcrt | 10q32.1 | 25723 | Rn0.7628 | |||||
OX1 receptor | Hypocretin (orexin) receptor 1 | Human | HCRTR1 | 1p35.2 | N.A. | 3061 | Hs0.388226 | 4848 | 10009 |
Mouse | Hcrtr1 | 4qD2.2 | 23077 | Mm0.246595 | |||||
Rat | Hcrtrt | 5q36 | 25593 | Rn0.88262 | |||||
OX2 receptor | Hypocretin (orexin) receptor 2 | Human | HCRTR2 | 6p12.1 | N.A. | 3062 | Hs0.151624 | 4849 | 12968 |
Mouse | Hcrtr2 | 9qD | 387285 | Rn0.9893 | |||||
Rat | Hcrtr2 | 8q24 | 25605 | Mm0.335300 |