Genes identified as involved in mediating cisplatin resistance by gene transfer or siRNA inhibition
All genes confer cisplatin resistance, except G-catenin and CTR1, which confer sensitivity to cisplatin
| Gene | Regulation | Method | Reference |
|---|---|---|---|
| TMEM205 | Up | Gene transfer | Shen et al., 2010 |
| RAB8 | Up | Gene transfer | Shen and Gottesman, 2012 |
| GCF2/LRRFIP1a | Up | Gene transfer/siRNA | Shen et al., 2012 |
| PCAF (p300/CBP-associated factor) | Up | Gene transfer | Hirano et al., 2010 |
| G-catenin | Down | Gene transfer | Liang et al., 2004 |
| Nrf2 | Up | siRNA | Cho et al., 2008 |
| HSP10, 27, 60 70, 90 | Up | Gene transfer/gene expression | Mandic et al., 2003; Zhao and Houry, 2005; Shen et al., 2006 |
| RPL36 | Up | Gene transfer | Shen et al., 2006 |
| SIRT1 | Up | Gene transfer/siRNA | Liang et al., 2008 |
| CTR1 | Down | Gene knockout | Howell et al., 2010 |
| ATP7A/B | Up | Gene transfer | Owatari et al., 2007; Safaei et al., 2008 |
| Tip60 | Up | Knockdown | Miyamoto et al., 2008 |
| TWIST, Snail | Up | siRNA | Zhuo et al., 2008a,b |
↵a GCF2/LRRFIP1 is shown to be upregulated in CP-r cells, repressing the expression of the microfilament regulator RhoA, disrupting trafficking of transporters to the cell surface, and conferring resistance to cisplatin.