Beneficial effects of the mood stabilizer VPA in multiple models of CNS disorders
Preclinical studies supporting the repurposing of VPA as a modulator of neuroprotection in various animal models of CNS diseases.
| Disease | Experimental models | References |
|---|---|---|
| Ischemic stroke | Rat and mouse MCAO models; rat global ischemia model | Ren et al., 2004; Kim et al., 2007; Qian et al., 2010; Tsai et al., 2011; Wang et al., 2011a, 2012; Xuan et al., 2012 |
| Hemorrhagic stroke | Rat intracerebral hemorrhagic model | Sinn et al., 2007 |
| TBI | Rat model of controlled cortical impact | Dash et al., 2010 |
| HD | Transgenic mice | Zadori et al., 2009; Chiu et al., 2011; |
| AD | Cultured cells and hippocampal slices; transgenic mice; Drosophila | Su et al., 2004; Qing et al., 2008; Smith et al., 2010; Hu et al., 2011 |
| ALS | Transgenic mice | Sugai et al., 2004; Rouaux et al., 2007; Feng et al., 2008 |
| FXS | FXS lymphoblastoid cell lines | Tabolacci et al., 2005, 2008 |
| PD | LPS-treated midbrain neuron-glia co-cultures; cellular, rat and mouse MPTP models; rotenone-challenged cellular and rat models | Peng et al., 2005; Chen et al., 2006, 2007; Wu et al., 2008; Castro et al., 2012; Kidd and Schneider, 2010, 2011; Monti et al., 2010; Xiong et al., 2011 |
| Retinal degeneration | Rat retinal ganglion cells; rat retinal ischemia model; optic nerve crush; mice | Biermann et al., 2010, 2011; Zhang et al., 2011b, 2012b |
| Spinal cord injury | Adult rats and mice; organotypic culture of spinal cord | Abematsu et al., 2010; Lv et al., 2011, 2012; Penas et al., 2011; Lee et al., 2012b |
| Spinal muscular atrophy | SMA fibroblast cell lines; transgenic mice | Sumner et al., 2003; Tsai et al., 2006, 2008; Harahap et al., 2012 |
| HIV-associated neurotoxicity | Mouse model of encephalitis; cultured neurons | Dou et al., 2005 |